Transcriptional activating regions target attached substrates to a cyclin-dependent kinase

Aseem Z. Ansari; Anuja Ogirala; Mark Ptashne

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Transcriptional activating regions target attached substrates to a cyclin-dependent kinase

机译：转录激活区域将附着的底物靶向细胞周期蛋白依赖性激酶

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The yeast cyclin-dependent kinase Srb10 phosphorylates various transcriptional activators as they activate transcription, and acidic transcriptional activating domains found on several activators directly bind Srb10. Here we show that the interaction between Srb10 (with its associated cyclin Srb11) and each of several different activating regions, in vitro, leads to the phosphorylation of peptide sequences attached to but outside of the activating regions themselves. In some cases, residues within the activating regions are also phosphorylated. The results define a mechanism by which a kinase is recruited to alternate substrates with diverse physiological consequences.

机译：酵母细胞周期蛋白依赖性激酶Srb10在激活转录时会将各种转录激活剂磷酸化，并且在几种激活剂上发现的酸性转录激活域直接结合Srb10。在这里，我们显示了Srb10（及其相关的细胞周期蛋白Srb11）与几个不同激活区域中的每一个之间的相互作用，在体外导致附着在激活区域本身之外的肽序列的磷酸化。在某些情况下，活化区内的残基也被磷酸化。结果定义了一种机制，通过该机制募集激酶以替代具有多种生理后果的底物。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2005年第7期|p.2346-2349|共4页
作者
Aseem Z. Ansari; Anuja Ogirala; Mark Ptashne;
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作者单位

Department of Biochemistry and Genome Center, University of Wisconsin, Madison, WI 53706;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
kinase-substrate targeting; proteolysis; Srb10/11; transcriptional regulation;

机译：激酶-底物靶向;蛋白水解;Srb10 / 11;转录调控;

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专利

1. Transcriptional activating regions target a cyclin-dependent kinase [J] . Aseem Z. Ansari, Sang Seok Koh, Zafar Zaman, Proceedings of the National Academy of Sciences of the United States of America . 2002,第23期

机译：转录激活区靶向细胞周期蛋白依赖性激酶
2. The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression. [J] . Yu JH, Zhu BM, Wickre M, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2010,第5期

机译：转录因子信号转导子和转录激活子5A（STAT5A）和STAT5B通过激活细胞周期蛋白依赖性激酶抑制剂2b（Cdkn2b）和Cdkn1a表达来负调控细胞增殖。
3. KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activity. [J] . M J Cismowski, G M Laff, M J Solomon, Molecular and Cellular Biology . 1995,第6期

机译：KIN28编码一个C末端结构域激酶，该激酶控制酿酒酵母中的mRNA转录，但缺乏细胞周期蛋白依赖性激酶激活激酶（CAK）活性。
4. Transcription factors and mitogen-activated protein kinases as molecular targets for chemoprevention with anti-inflammatory phytochemicals [C] . Young-Joon Surh, Hye-KyungNa, Seung Sei Lee International Conference on Food Factors . 2004

机译：转录因子和丝裂原激活蛋白激酶作为化学预防抗炎植物化学植物的分子靶标
5. Biochemical characterization of the cyclin-dependent kinase activating kinase from budding yeast [D] . Enke, Deborah Ann 1998

机译：发芽酵母细胞周期蛋白依赖性激酶激活激酶的生化特性
6. Transcriptional activating regions target attached substrates to a cyclin-dependent kinase [O] . Aseem Z. Ansari, Anuja Ogirala, Mark Ptashne 2005

机译：转录激活区域将附着的底物靶向细胞周期蛋白依赖性激酶
7. Transcriptional activating regions target attached substrates to a cyclin-dependent kinase [O] . Ansari, Aseem Z., Ogirala, Anuja, Ptashne, Mark 2005

机译：转录激活区域将附着的底物靶向细胞周期蛋白依赖性激酶
8. Regulation of Estrogen Receptor-Dependent Transcriptional Activation by a Cyclin-Dependent Kinase [R] . Trowbridge, J. M. 1998

机译：通过细胞周期蛋白依赖性激酶调节雌激素受体依赖性转录激活

Transcriptional activating regions target attached substrates to a cyclin-dependent kinase

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