Transcriptional activating regions target a cyclin-dependent kinase

Aseem Z. Ansari; Sang Seok Koh; Zafar Zaman; Christine Bongards; Norbert Lehming; Richard A. Young; Mark Ptashne

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Transcriptional activating regions target a cyclin-dependent kinase

机译：转录激活区靶向细胞周期蛋白依赖性激酶

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Several yeast activators are phosphorylated by SRB10, a cyclin-dependent kinase associated with the transcriptional machinery. Sites of phosphorylation are found outside the activating region in each case, and the modification has different physiological consequences in different cases. We show here that certain acidic transcriptional activating regions contact SRB10 as assayed both in vivo and in vitro. The interaction evidently positions each activator, as it activates transcription, so that it gets phosphorylated by SRB10, and thus a common mechanism targets disparate substrates to the kinase.

机译：几种酵母激活剂被SRB10磷酸化，SRB10是一种与转录机制相关的细胞周期蛋白依赖性激酶。在每种情况下，都在活化区域之外发现磷酸化位点，并且在不同情况下，修饰具有不同的生理学后果。我们在这里显示某些酸性转录激活区接触SRB10，如体内和体外测定。相互作用显然会激活每个激活因子，从而激活转录，从而使其被SRB10磷酸化，因此一种共同的机制会将不同的底物靶向该激酶。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第23期|p.14706-14709|共4页
作者
Aseem Z. Ansari; Sang Seok Koh; Zafar Zaman; Christine Bongards; Norbert Lehming; Richard A. Young; Mark Ptashne;
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作者单位

Program in Molecular Biology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Transcriptional activating regions target attached substrates to a cyclin-dependent kinase [J] . Aseem Z. Ansari, Anuja Ogirala, Mark Ptashne Proceedings of the National Academy of Sciences of the United States of America . 2005,第7期

机译：转录激活区域将附着的底物靶向细胞周期蛋白依赖性激酶
2. The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression. [J] . Yu JH, Zhu BM, Wickre M, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2010,第5期

机译：转录因子信号转导子和转录激活子5A（STAT5A）和STAT5B通过激活细胞周期蛋白依赖性激酶抑制剂2b（Cdkn2b）和Cdkn1a表达来负调控细胞增殖。
3. KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activity. [J] . M J Cismowski, G M Laff, M J Solomon, Molecular and Cellular Biology . 1995,第6期

机译：KIN28编码一个C末端结构域激酶，该激酶控制酿酒酵母中的mRNA转录，但缺乏细胞周期蛋白依赖性激酶激活激酶（CAK）活性。
4. Transcription factors and mitogen-activated protein kinases as molecular targets for chemoprevention with anti-inflammatory phytochemicals [C] . Young-Joon Surh, Hye-KyungNa, Seung Sei Lee International Conference on Food Factors . 2004

机译：转录因子和丝裂原激活蛋白激酶作为化学预防抗炎植物化学植物的分子靶标
5. Biochemical characterization of the cyclin-dependent kinase activating kinase from budding yeast [D] . Enke, Deborah Ann 1998

机译：发芽酵母细胞周期蛋白依赖性激酶激活激酶的生化特性
6. Transcriptional activating regions target attached substrates to a cyclin-dependent kinase [O] . Aseem Z. Ansari, Anuja Ogirala, Mark Ptashne 2005

机译：转录激活区域将附着的底物靶向细胞周期蛋白依赖性激酶
7. Transcriptional activating regions target attached substrates to a cyclin-dependent kinase [O] . Ansari, Aseem Z., Ogirala, Anuja, Ptashne, Mark 2005

机译：转录激活区域将附着的底物靶向细胞周期蛋白依赖性激酶
8. Regulation of Estrogen Receptor-Dependent Transcriptional Activation by a Cyclin-Dependent Kinase [R] . Trowbridge, J. M. 1998

机译：通过细胞周期蛋白依赖性激酶调节雌激素受体依赖性转录激活

Transcriptional activating regions target a cyclin-dependent kinase

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