...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling
【24h】

Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling

机译：细胞因子信号传导（SOCS）-5的抑制因子是表皮生长因子信号传导的潜在负调控因子

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The suppressors of cytokine signaling (SOCS) proteins are a family of SH2 domain-containing intracellular inhibitors of cytokine signal transduction that act by several different mechanisms. Recent evidence suggests that the action of the SOCS proteins may extend beyond the cytokine receptors to signaling initiated by members of the tyrosine kinase receptor family. In this study, the ability of SOCS-5 to negatively regulate signaling cascades downstream of the epidermal growth factor receptor (EGF-R) has been examined by using an EGF-responsive cell line engineered to constitu-tively express the EGF-R and SOCS-5 or SOCS-5 mutants. SOCS-5 associated with the EGF-R complex in an EGF-independent manner, and the mitogenic response to EGF of all SOCS-5-expressing cell lines was dramatically inhibited when compared with control cell lines. Furthermore, this effect was abrogated after deletion of the SOCS-5 SOCS box. This result suggests that the inhibition of signaling occurs through enhanced proteasomal degradation of the EGF-R through SOCS box recruitment of E3 ubiquitin ligase activity.
机译：细胞因子信号转导（SOCS）蛋白的抑制剂是一类包含SH2结构域的细胞因子信号转导的细胞内抑制剂，它们通过几种不同的机制起作用。最近的证据表明，SOCS蛋白的作用可能扩展到细胞因子受体之外，进而扩展到酪氨酸激酶受体家族成员发起的信号转导。在这项研究中，通过使用经工程改造以组成型表达EGF-R和SOCS的EGF反应细胞系，研究了SOCS-5对表皮生长因子受体（EGF-R）下游信号传导级联反应负调控的能力。 -5或SOCS-5突变体。与对照细胞系相比，SOCS-5以EGF无关的方式与EGF-R复合物相关，并且所有表达SOCS-5的细胞系对EGF的促有丝分裂反应均受到显着抑制。此外，删除SOCS-5 SOCS框后，该效果被取消。该结果表明信号传导的抑制是通过E3泛素连接酶活性的SOCS盒募集通过增强的EGF-R的蛋白酶体降解而发生的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号