...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Uric acid protects against secondary damage after spinal cord injury
【24h】

Uric acid protects against secondary damage after spinal cord injury

机译：尿酸可防止脊髓损伤后的继发性损伤

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Peroxynitrite contributes to the pathogenesis of various neurode-generative disorders through multiple mechanisms and is thought to mediate secondary neuronal cell death after spinal cord injury (SCI). Here we establish that physiologically relevant levels of uric acid (UA), a selective inhibitor of certain peroxynitrite-mediated reactions, block the toxic effects of peroxynitrite on primary spinal cord neurons in vitro. Furthermore, administration of UA at the onset of SCI in a mouse model inhibits several pathological changes in the spinal cord including general tissue damage, nitrotyrosine formation, lipid peroxidation, activation of poly(ADP-ribose) poly-merase, and neutrophil invasion. More importantly, UA treatment improves functional recovery from the injury. Taken together, our findings support the concept that peroxynitrite contributes to the pathophysiology of secondary damage after SCI. They also raise the possibility that elevating UA levels may provide a therapeutic approach for the treatment of SCI as well as other neurological diseases with a peroxynitrite-mediated pathological component.
机译：过氧亚硝酸盐通过多种机制促成各种神经退行性疾病的发病机理，并被认为可介导脊髓损伤（SCI）后继发性神经元细胞死亡。在这里，我们建立了生理相关水平的尿酸（UA），某些过氧亚硝酸盐介导的反应的选择性抑制剂，阻断了过氧亚硝酸盐对体外初级脊髓神经元的毒性作用。此外，在小鼠模型中，在SCI发作时施用UA可以抑制脊髓的几种病理变化，包括一般组织损伤，硝基酪氨酸形成，脂质过氧化，聚（ADP-核糖）聚合酶的活化和嗜中性白细胞的侵袭。更重要的是，UA治疗可改善损伤的功能恢复。综上所述，我们的发现支持了过氧亚硝酸盐有助于SCI后继发性损伤的病理生理的概念。他们还增加了UA水平升高可能为过氧亚硝酸盐介导的病理成分提供治疗SCI以及其他神经系统疾病的治疗方法的可能性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号