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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Time for chronotherapy? Clock genes dictate sensitivity to cyclophosphamide
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Time for chronotherapy? Clock genes dictate sensitivity to cyclophosphamide

机译：是时候进行时间疗法了吗？时钟基因决定了对环磷酰胺的敏感性

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摘要

Temporal Organization of Biological processes is a critical feature of life. In addition to orderly, carefully timed developmental processes, precise temporal organization is also observed on a daily time scale. On Earth, organisms ranging from bacteria to humans have evolved internal timekeeping mechanisms called circadian clocks that control biochemistry, physiology, and behavior to coordinate with the 24-hour day. Circadian clocks have long been known to drive rhythms in such things as activity, sleep, and hormone secretion, but in recent years it has become clear that these clocks influence the normal ho-meostasis of organisms on a profound scale, controlling processes as diverse as cell cycle regulation, cell signaling, metabolic events, and cognitive function.
机译：生物过程的时间组织是生命的重要特征。除了有序，精心安排的发育过程外，还可以在每天的时间尺度上观察到精确的时间组织。在地球上，从细菌到人类不等的生物已经进化了称为生物钟的内部计时机制，该生物钟控制生物化学，生理学和行为，以与一天24小时协调。昼夜节律钟在活动，睡眠和荷尔蒙分泌等方面可引起节律，但近年来已清楚地认识到，这些钟节对生物体正常的稳态具有深远的影响，控制着各种各样的过程。细胞周期调节，细胞信号传导，代谢事件和认知功能。

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