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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Rates of intron loss and gain: Implications for early eukaryotic evolution
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Rates of intron loss and gain: Implications for early eukaryotic evolution

机译：内含子丢失和获得的速率：对早期真核生物进化的启示

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摘要

We study the intron-exon structures of 684 groups of orthologs from seven diverse eukaryotic genomes and provide maximum likelihood estimates for rates and numbers of intron losses and gains in these same genes for a variety of lineages. Rates of intron loss vary from ≈2 x 10~(-9) to 2 x 10~(-10) per year. Rates of gain vary from 6 x 10~(-13) to 4 x 10~(-12) per possible intron insertion site per year. There is an inverse correspondence between rates of intron loss and gain, leading to a 20-fold variation among lineages in the ratio of the rates of the two processes. The observed rates of intron gain are insufficient to explain the large number of introns estimated to have been present in the plant-animal ancestor, suggesting that introns present in early eukaryotes may have been created by a fundamentally different process than more recently gained introns.
机译：我们研究了来自七个不同的真核生物基因组的684组直系同源物的内含子-外显子结构，并为这些谱系的这些相同基因的内含子丢失和获得的速率和数量提供了最大似然估计。内含子的损失率每年从≈2x 10〜（-9）到2 x 10〜（-10）不等。每年每个可能的内含子插入位点的增益速率从6 x 10〜（-13）到4 x 10〜（-12）不等。内含子损失率和获得率之间存在反比关系，导致两个过程的比率之比在谱系中变化20倍。观察到的内含子增加速率不足以解释估计存在于植物-动物祖先中的大量内含子，这表明早期真核生物中存在的内含子可能是由与最近获得的内含子根本不同的过程产生的。

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