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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Noncholinergic excitatory actions of motoneurons in the neonatal mammalian spinal cord
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Noncholinergic excitatory actions of motoneurons in the neonatal mammalian spinal cord

机译：运动神经元对新生哺乳动物脊髓的非胆碱能兴奋作用

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摘要

Mammalian spinal motoneurons are considered to be output elements of the spinal cord that generate exclusively cholinergic actions on Renshaw cells, their intraspinal synaptic targets. Here, we show that antidromic stimulation of motor axons evokes depolarizing monosynaptic potentials in Renshaw cells that are depressed, but not abolished, by cholinergic antagonists. This residual potential was abolished by 2-amino-5-phosphonovaleric acid and 6-cyano-7-nitroquinoxaline-2,3-dione. In the presence of cholinergic antagonists, motor axon stimulation triggered locomo-tor-like activity that was blocked by 2-amino-5-phosphonovaleric acid. Some cholinergic motoneuronal terminals on both Renshaw cells and motoneurons were enriched in glutamate, but none expressed vesicular glutamate transporters. Our results raise the possibility that motoneurons release an excitatory amino acid in addition to acetylcholine and that they may be more directly involved in the genesis of mammalian locomotion than previously believed.
机译：哺乳动物的脊髓运动神经元被认为是脊髓的输出元件，仅对Renshaw细胞（它们的脊柱内突触靶标）产生胆碱能作用。在这里，我们表明，对运动轴突的反激刺激在胆碱能拮抗剂抑制但并未消除的Renshaw细胞中引起去极化单突触电位。该残留电位被2-氨基-5-膦戊酸和6-氰基-7-硝基喹喔啉-2,3-二酮消除。在存在胆碱能拮抗剂的情况下，运动轴突刺激触发了类似2-5-5-膦酸戊酸被阻断的类似locomotor的活动。 Renshaw细胞和运动神经元上的一些胆碱能神经元末端富含谷氨酸，但没有表达囊泡谷氨酸转运蛋白。我们的结果提高了运动神经元除乙酰胆碱之外还释放出兴奋性氨基酸的可能性，并且它们可能比以前认为的更直接地参与了哺乳动物运动的发生。

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