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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Efficient hepatitis C virus cell culture system: What a difference the host cell makes
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Efficient hepatitis C virus cell culture system: What a difference the host cell makes

机译：高效的丙型肝炎病毒细胞培养系统：宿主细胞产生什么变化

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摘要

The availability of a cell culture system is a critical prerequisite to study the replication cycle of a virus and to devise strategies for prophylactic and therapeutic interventions. Such a system depends on two elementary components: an infectable host cell supporting production of infectious virus progeny and a virus that is capable of replicating and assembling infectious particles in these cells. From a technical point of view this is relatively easy to achieve, but what if the virus does not replicate in cultured cells? There are several examples of medically very important viruses that cannot or can only poorly be propagated in cell culture, hepatitis C virus (HCV) being one prominent example. All attempts to culture this pathogen have been faced with major roadblocks that could be overcome only step-by-step.
机译：细胞培养系统的可用性是研究病毒复制周期并设计预防和治疗措施的关键前提。这样的系统取决于两个基本组成部分：支持传染性病毒后代产生的可感染宿主细胞和能够在这些细胞中复制和组装感染性颗粒的病毒。从技术角度来看，这相对容易实现，但是如果病毒不能在培养的细胞中复制怎么办？医学上非常重要的病毒有几个例子，它们不能或只能在细胞培养中很难传播，丙型肝炎病毒（HCV）是一个突出的例子。培养这种病原体的所有尝试都面临着主要的障碍，这些障碍只能逐步解决。

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