...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Dopamine responsiveness is regulated by targeted sorting of D2 receptors
【24h】

Dopamine responsiveness is regulated by targeted sorting of D2 receptors

机译：多巴胺反应性受D2受体的靶向分选调节

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aberrant dopaminergic signaling is a critical determinant in multiple psychiatric disorders, and in many disease states, dopamine receptor number is altered. Here we identify a molecular mechanism that selectively targets D2 receptors for degradation after their activation by dopamine. The degradative fate of D2 receptors is determined by an interaction with G protein coupled receptor-associated sorting protein (GASP). As a consequence of this GASP interaction, D2 responses in rat brain fail to resensitize after agonist treatment. Disruption of the D2-GASP interaction facilitates recovery of D2 responses, suggesting that modulation of the D2-GASP interaction is important for the functional down-regulation of D2 receptors.
机译：多巴胺能异常信号是多种精神病的关键决定因素，在许多疾病中，多巴胺受体的数量都会改变。在这里，我们确定了一种分子机制，该机制选择性地靶向D2受体被多巴胺激活后降解。 D2受体的降解命运取决于与G蛋白偶联受体相关分选蛋白（GASP）的相互作用。这种GASP相互作用的结果是，激动剂治疗后，大鼠大脑中的D2反应无法重新敏感。 D2-GASP相互作用的破坏促进了D2反应的恢复，这表明D2-GASP相互作用的调节对于D2受体的功能下调很重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号