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TETRAHYDROPYRIDIN-4-IL INDOLES WITH A COMBINATION OF PROPERTIES-RELATIONSHIPS FOR D2 DOPAMINE RECEPTORS D2 AND SEROTONIN REVERSION CENTERS
TETRAHYDROPYRIDIN-4-IL INDOLES WITH A COMBINATION OF PROPERTIES-RELATIONSHIPS FOR D2 DOPAMINE RECEPTORS D2 AND SEROTONIN REVERSION CENTERS
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机译：D2多巴胺受体D2和5-羟色胺活性中心结合特性关系的四氢吲哚-4-IL吲哚
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摘要
The present invention relates to a group of novel tetrahydropyridin-4-yl indoles with a dual mode of action: serotonin reuptake inhibition and affinity for dopamine -DSUB2/SUB receptors, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said tetrahydropyridin-4-yl indoles. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The invention relates to novel tetrahydropyridin -4-yl indoles of the formula (I) and tautomers, stereoisomers, prodrugs, N -oxides, pharmacologically acceptable salts, hydrates and solvates thereof , wherein: - RSUB1/SUB is hydrogen, halogen, alkyl (CSUB1-3/SUB) or alkoxy(CSUB1-3/SUB), CN or CFSUB3/SUB, - RSUB2/SUB is hydrogen or alkyl (CSUB1-3/SUB), RSUB3/SUB is hydrogen or alkyl (CSUB1-3/SUB), - Z is hydrogen or alkyl (CSUB1-3/SUB), alkoxy(CSUB1-3/SUB) or alkylthio(CSUB1-3/SUB), - A is hydrogen or alkyl (CSUB1-3/SUB), or - A and Z together form a saturated or (partly) unsaturated 5 - or 6- membered ring which may be substituted with halogen, alkyl (CSUB1-3/SUB) or phenyl, in which ring Z represents carbon, sulfur of nitrogen .
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