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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Cationic liposome-microtubule complexes: Pathways to the formation of two-state lipid-protein nanotubes with open or closed ends
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Cationic liposome-microtubule complexes: Pathways to the formation of two-state lipid-protein nanotubes with open or closed ends

机译：阳离子脂质体-微管复合物：形成具有开放或封闭末端的两态脂质-蛋白质纳米管的途径

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摘要

Intermolecular interactions between charged membranes and biological polyelectrolytes, tuned by physical parameters, which include the membrane charge density and bending rigidity, the membrane spontaneous curvature, the biopolymer curvature, and the overall charge of the complex, lead to distinct structures and morphologies. The self-assembly of cationic liposome-microtubule (MT) complexes was studied, using synchrotron x-ray scattering and electron microscopy. Vesicles were found to either adsorb onto MTs, forming a "beads on a rod" structure, or undergo a wetting transition and coating the MT. Tubulin oligomers then coat the external lipid layer, forming a tunable lipid-protein nanotube. The beads on a rod structure is a kinetically trapped state. The energy barrier between the states depends on the membrane bending rigidity and charge density. By controlling the cationic lipid/tubulin stoichiometry it is possible to switch between two states of nanotubes with either open ends or closed ends with lipid caps, a process that forms the basis for controlled chemical and drug encapsulation and release.
机译：带电的膜和生物聚电解质之间的分子间相互作用，通过物理参数进行调整，包括膜电荷密度和弯曲刚度，膜自发曲率，生物聚合物曲率以及复合物的总电荷，导致结构和形态各异。使用同步加速器X射线散射和电子显微镜研究了阳离子脂质体-微管（MT）配合物的自组装。发现囊泡吸附到MT上，形成“棒上的珠子”结构，或经历润湿转变并涂覆MT。然后微管蛋白寡聚物包被外部脂质层，形成可调的脂质-蛋白质纳米管。杆结构上的珠粒是动力学捕获状态。状态之间的能垒取决于膜的弯曲刚度和电荷密度。通过控制阳离子脂质/微管蛋白的化学计量，可以在带有脂帽的开放端或封闭端的纳米管的两种状态之间切换，这一过程为受控的化学和药物封装与释放奠定了基础。

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