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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction
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Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction

机译：心肌梗死后心肌内注射同种异体间充质干细胞进行心脏修复

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摘要

Although clinical trials of autologous whole bone marrow for cardiac repair demonstrate promising results, many practical and mechanistic issues regarding this therapy remain highly controversial. Here, we report the results of a randomized study of bone-marrow-derived mesenchymal stem cells, administered to pigs, which offer several new insights regarding cellular cardio-myoplasty. First, cells were safely injected by using a percutaneous-injection catheter 3 d after myocardial infarction. Second, cellular transplantation resulted in long-term engraftment, profound reduction in scar formation, and near-normalization of cardiac function. Third, transplanted cells were preprepared from an allogeneic donor and were not rejected, a major practical advance for widespread application of this therapy. Together, these findings demonstrate that the direct injection of cellular grafts into damaged myocardium is safe and effective in the periinfarct period. The direct delivery of cells to necrotic myocardium offers a valuable alternative to intracoronary cell injections, and the use of allogeneic mesenchymal stem cells provides a valuable strategy for cardiac regenerative therapy that avoids the need for preparing autologous cells from the recipient.
机译：尽管自体全骨髓用于心脏修复的临床试验显示出令人鼓舞的结果，但有关该疗法的许多实际和机制问题仍存在很大争议。在这里，我们报告了对猪施用的骨髓来源的间充质干细胞的随机研究结果，该研究为细胞心肌肌成形术提供了一些新见解。首先，在心肌梗塞后3天通过使用经皮注射导管安全地注射细胞。其次，细胞移植导致长期植入，疤痕形成的明显减少以及心脏功能的接近正常化。第三，移植的细胞是由同种异体供体制备的，没有被拒绝，这是该疗法广泛应用的重大实践进展。总之，这些发现表明，在梗死期周围，将细胞移植物直接注射到受损的心肌中是安全有效的。将细胞直接递送至坏死的心肌提供了冠状动脉内注射的有价值的替代方法，同种异体间充质干细胞的使用为心脏再生治疗提供了有价值的策略，从而避免了从接受者制备自体细胞的需要。

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