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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Juxtanodin: An oligodendroglial protein that promotes cellular arborization and 2′,3′-cyclic nucleotide-3′-phosphodiesterase trafficking
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Juxtanodin: An oligodendroglial protein that promotes cellular arborization and 2′,3′-cyclic nucleotide-3′-phosphodiesterase trafficking

机译：Juxtanodin：一种少突胶质蛋白，可促进细胞乔化和2'，3'-环核苷酸3'-磷酸二酯酶的运输

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摘要

In the process of screening cell-type-specific genes, we identified juxtanodin (JN), an oligodendroglial protein featuring a putative C-terminal actin-binding domain. At the cellular level, JN in the rat CNS colocalized with 2′,3′-cyclic nucleotide-3′-phosphodiesterase (CNPase), a cytoskeleton-related oligodendroglial protein. In the myelin sheath, JN was found mainly in the abaxon and the lateral few terminal loops. Its apposition to the myelinated axon, through the latter, defined an axonal subregion, herewith termed juxta-node, at the Ranvier node-paranode junction. During forebrain ontogenesis, JN expression paralleled that of MBPs but lagged behind CNPase. Juxtanodin transfection promoted arborization of cultured OLN-93 cells and augmented endogenous CNPase expression and transport to the process arbors of cultured primary oligodendrocyte precursors. These results reveal JN as a cytoskeleton-related oligodendroglial protein that delineates the juxtan-ode and might serve oligodendrocyte motility, differentiation, or myelin-axon signaling. Functionally, JN may be involved in CNS myelination and/or specialization of the node of Ranvier.
机译：在筛选特定于细胞类型的基因的过程中，我们鉴定出了Juxtanodin（JN），这是一种以假定的C端肌动蛋白结合域为特征的少突胶质蛋白。在细胞水平上，大鼠中枢神经系统中的JN与2'，3'-环状核苷酸3'-磷酸二酯酶（CNPase）共定位，CNPase是一种细胞骨架相关的少突胶质蛋白。在髓鞘中，JN主要存在于abaxon和侧面的少数末端环中。它通过髓质轴突与轴突的并置，在Ranvier节点-对节节点的交界处定义了一个轴突子区域，在此称为轴突节点。在前脑癌发生过程中，JN表达与MBP相似，但落后于CNPase。 Juxtanodin转染促进培养的OLN-93细胞的乔化，并增强内源性CNPase的表达和转运至培养的少突胶质前体细胞的前突。这些结果表明，JN是一种细胞骨架相关的少突胶质蛋白，描绘了并列胶结，并可能有助于少突胶质细胞的运动性，分化或髓鞘-轴突信号转导。在功能上，JN可能参与Ranvier节点的CNS髓鞘化和/或特化。

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