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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Neural mechanism in anterior prefrontal cortex for inhibition of prolonged set interference
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Neural mechanism in anterior prefrontal cortex for inhibition of prolonged set interference

机译：前额叶皮层抑制长时程干扰的神经机制

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摘要

Once one cognitive set dominates our behavior, it continues to influence subsequent behavior for a while even after a task to be performed is changed to another. Despite abundant knowledge of the inhibitory mechanisms that are recruited at the first trial after the change (the first inhibition trial), little is known about the inhibition of prolonged proactive interference from a previous set that lingers for several trials after the first inhibition trial. The present functional MRI study explored the neural mechanisms for inhibition of a previous set that were recruited after the first inhibition trial. A modified Wisconsin Card Sorting Test was used where "dual-match stimuli" were intermittently presented and allowed subjects to perform correctly based on previously appropriate, now inappropriate, responses. In response to the dual-match stimulus at "release" trials presented after the first inhibition trials, the subjects were transiently exempted from inhibiting the prolonged previous set. As expected from the exempted inhibitory demands, significant reaction time decrease was revealed in the release trials. Consistent with the behavioral results, transient signal decrease time-locked to the release trials was revealed in the left anterior part of the superior frontal sulcus. Moreover, the anterior prefrontal region was not sensitive to the task change, which exhibited a marked contrast to the left posterior inferior prefrontal region that showed significant signal changes in both events. These results revealed multiple inhibitory mechanisms in the lateral prefrontal cortex that are recruited in different temporal contexts of the interference from a previous cognitive set.
机译：一旦一个认知集合支配了我们的行为，即使将要执行的任务变为另一个任务，它也会继续影响随后的行为一段时间。尽管在更改后的第一个试验（第一个抑制试验）中招募了很多抑制机制的知识，但对于先前的抑制长期干扰的了解却很少，而在第一个抑制试验后的几项试验中仍存在这种干扰。目前的功能性MRI研究探索了抑制第一个抑制试验后募集的先前药物的神经机制。使用改良的威斯康星卡片分类测试，在这种测试中，间歇性地展示“双重比赛刺激”，并根据先前适当的，现在不合适的反应让受试者正确地进行表演。在首次抑制试验后对“释放”试验中的双重匹配刺激做出反应后，受试者被暂时免于抑制延长的先前试验。如获豁免的抑制要求所预期，释放试验表明反应时间显着减少。与行为结果一致，在额叶上沟的左前部揭示了暂时性的，与释放试验锁定时间相关的信号降低。此外，前额叶前区对任务变化不敏感，与左后下额叶前额叶区显示出明显的对比，后者在两个事件中均显示出明显的信号变化。这些结果揭示了在外侧前额叶皮层的多种抑制机制，这些机制是在先前认知障碍的不同时间背景下募集的。

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