首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Inositol polyphosphate multikinase is a nuclear P13-kinase with transcriptional regulatory activity
【24h】

Inositol polyphosphate multikinase is a nuclear P13-kinase with transcriptional regulatory activity

机译:肌醇多磷酸多激酶是一种具有转录调节活性的核P13激酶

获取原文
获取原文并翻译 | 示例
           

摘要

Phosphatidylinositol 3,4,5-trisphosphate is a major intracellular messenger molecule thought to be formed almost exclusively by cytosolic, wortmannin-inhibited phosphoinositide 3-kinase family members. Inositol polyphosphate multikinase was identified as an enzyme that generates a series of water-soluble inositol phosphates. We now report the robust, physiologic, and evolutionarily conserved phosphoinositide 3-kinase activity of inositol polyphosphate multikinase, which is localized to nuclei and unaffected,by wortmannin. In yeast, this inositol lipid kinase activity physiologically regulates transcription.
机译:磷脂酰肌醇3,4,5-三磷酸酯是一种主要的细胞内信使分子,被认为几乎完全由胞浆,渥曼青霉素抑制的磷酸肌醇3-激酶家族成员形成。肌醇多磷酸多激酶被鉴定为可产生一系列水溶性肌醇磷酸的酶。现在,我们报告肌醇多磷酸多激酶的稳健,生理和进化保守的磷酸肌醇3激酶活性,它被渥曼青霉素定位于细胞核且不受影响。在酵母中,这种肌醇脂质激酶活性在生理上调节转录。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号