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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Mimivirus gene promoters exhibit an unprecedented conservation among all eukaryotes.
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Mimivirus gene promoters exhibit an unprecedented conservation among all eukaryotes.

机译：拟病毒基因启动子在所有真核生物中均表现出前所未有的保守性。

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摘要

The initial analysis of the recently sequenced genome of Acanthamoeba polyphaga Mimivirus, the largest known double-stranded DNA virus, predicted a proteome of size and complexity more akin to small parasitic bacteria than to other nucleocytoplasmic large DNA viruses and identified numerous functions never before described in a virus. It has been proposed that the Mimivirus lineage could have emerged before the individualization of cellular organisms from the three domains of life. An exhaustive in silico analysis of the noncoding moiety of all known viral genomes now uncovers the unprecedented perfect conservation of an AAAATTGA motif in close to 50% of the Mimivirus genes. This motif preferentially occurs in genes transcribed from the predicted leading strand and is associated with functions required early in the viral infectious cycle, such as transcription and protein translation. A comparison with the known promoter of unicellular eukaryotes, amoebal protists in particular, strongly suggests that the AAAATTGA motif is the structural equivalent of the TATA box core promoter element. This element is specific to the Mimivirus lineage and may correspond to an ancestral promoter structure predating the radiation of the eukaryotic kingdoms. This unprecedented conservation of core promoter regions is another exceptional feature of Mimivirus that again raises the question of its evolutionary origin.
机译：最初对最大的已知双链DNA病毒棘阿米巴多噬菌拟南芥病毒的基因组进行的初步分析预测，蛋白质组蛋白的大小和复杂性更类似于小型寄生细菌，而不是其他核质大DNA病毒，并且确定了许多以前从未描述过的功能。病毒。有人提出，在生命的三个领域将细胞有机体个体化之前，可能已经出现了模仿病毒谱系。现在，对所有已知病毒基因组的非编码部分进行详尽的计算机分析，发现在近50％的拟病毒基因中，AAAATTGA基序具有前所未有的完美保守性。该基序优先出现在从预测的前导链转录的基因中，并且与病毒感染周期早期所需的功能（例如转录和蛋白质翻译）相关。与已知的单细胞真核生物启动子（尤其是变形虫的原生生物）的比较强烈表明，AAAATTGA基序与TATA框核心启动子元件的结构等同。该元件是特定于Mimivirus谱系的，可能对应于先于真核生物辐射的祖先启动子结构。核心启动子区域的这种空前的保护是拟病毒的另一个特殊特征，再次引起了其进化起源的问题。

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