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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Diapause in the mosquito Culex pipiens evokes a metabolic switch from blood feeding to sugar gluttony
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Diapause in the mosquito Culex pipiens evokes a metabolic switch from blood feeding to sugar gluttony

机译：蚊子的滞育导致淡色库蚊引发了从供血到糖暴食的新陈代谢转换

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摘要

A key characteristic of overwintering dormancy (diapause) in the mosquito Culex pipiens is the switch in females from blood feeding to sugar gluttony. We present evidence demonstrating that genes encoding enzymes needed to digest a blood meal (trypsin and a chymotrypsin-like protease) are down-regulated in diapause-destined females, and that concurrently, a gene associated with the accumulation of lipid reserves (fatty add synthase) is highly up-regulated. As the females then enter diapause, fatty acid synthase is only sporadically expressed, and expression of trypsin and chymotrypsin-like remains undetectable. Late in diapause (2-3 months at 18℃), the genes encoding the digestive enzymes begin to be expressed as the female prepares to take a blood meal upon the termination of diapause. Our results thus underscore a molecular switch that either capacitates the mosquito for blood feeding (nondiapause) or channels the adult mosquito exclusively toward sugar feeding and lipid sequestration (diapause).
机译：蚊子库蚊（Colex pipiens）的越冬休眠（暂停）的一个关键特征是雌性动物从供血转变为糖暴食。我们目前的证据表明，在滞育期雌性动物中，编码消化血粉所需的酶（胰蛋白酶和胰凝乳蛋白酶样蛋白酶）的基因被下调，并且与此同时，与脂质储备积累相关的基因（脂肪添加合酶）高度上调。当雌性随后进入滞育期时，脂肪酸合酶仅偶发地表达，而胰蛋白酶和胰凝乳蛋白酶样的表达仍然不可检测。滞育后期（在18摄氏度下需要2-3个月），随着滞育终止，女性准备进食，开始表达编码消化酶的基因。因此，我们的结果强调了一种分子开关，该开关既可以使蚊子吸血（不滞血），也可以将成年蚊子专门引导向食糖和脂质螯合（滞血）。

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