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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Normal motor learning during pharmacological prevention of Purkinje cell long-term depression.
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Normal motor learning during pharmacological prevention of Purkinje cell long-term depression.

机译：药理预防浦肯野细胞长期抑郁症期间的正常运动学习。

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摘要

Systemic delivery of (1R-1-benzo thiophen-5-yl-2[2-diethylamino)-ethoxy] ethanol hydrochloride (T-588) prevented long-term depression (LTD) of the parallel fiber (PF)-Purkinje cell (PC) synapse induced by conjunctive climbing fiber and PF stimulation in vivo. However, similar concentrations of T-588 in the brains of behaving mice and rats affected neither motor learning in the rotorod test nor the learning of motor timing during classical conditioning of the eyeblink reflex. Rats given doses of T-588 that prevented PF-PC LTD were as proficient as controls in learning to adapt the timing of their conditioned eyeblink response to a 150- or 350-ms change in the timing of the paradigm. The experiment indicates that PF-PC LTD under control of the climbing fibers is not required for general motor adaptation or the learning of response timing in two common models of motor learning for which the cerebellum has been implicated. Alternative mechanisms for motor timing and possible functions for LTD in protectionfrom excitotoxicity are discussed.
机译：（1R-1-苯并噻吩-5-基-2 [2-二乙基氨基）-乙氧基]乙醇盐酸盐（T-588）的全身输送可防止平行纤维（PF）-Purkinje细胞（ PC）在体内通过结缔性攀爬纤维和PF刺激诱导的突触。然而，行为小鼠和大鼠大脑中相似浓度的T-588既不会影响旋翼测试中的运动学习，也不会影响经典眨眼反射条件下运动时间的学习。给予预防PF-PC LTD的T-588剂量的大鼠与对照组一样熟练地学习了使其条件性眨眼反应的时间适应范式的时间变化150-或350-ms。实验表明，在涉及小脑的两种常见的运动学习模型中，对于一般的运动适应或学习响应时机，不需要在攀登纤维控制下的PF-PC LTD。讨论了电动机正时的替代机制以及LTD在防止兴奋性毒性中的可能功能。

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