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首页> 外文期刊>The European Journal of Neuroscience >Simple spike and complex spike activity of floccular Purkinje cells during the optokinetic reflex in mice lacking cerebellar long-term depression.
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Simple spike and complex spike activity of floccular Purkinje cells during the optokinetic reflex in mice lacking cerebellar long-term depression.

机译：在缺乏小脑长期抑郁症的小鼠的视动反射期间，絮状浦肯野细胞的简单加标和复杂加标活性。

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摘要

Cerebellar long-term depression (LTD) at parallel fibre-Purkinje cell (P-cell) synapses is thought to embody neuronal information storage for motor learning. Transgenic L7-protein kinase C inhibitor (PKCI) mice in which cerebellar LTD is selectively blocked do indeed exhibit impaired adaptation in the vestibulo-ocular reflex (VOR) while their default oculomotor performance is unaffected. Although supportive, these data do not definitively establish a causal link between memory storage required for motor learning and cerebellar LTD. As the L7-PKCI transgene is probably activated from the early stages of P-cell development, an alternative could be that P-cells develop abnormal signals in L7-PKCI mutants, disturbing mechanisms of motor learning that rely on proper P-cell outputs. To test this alternative hypothesis, we studied simple spike (SS) and complex spike (CS) activity of vertical axis P-cells in the flocculus of L7-PKCI mice and their wild-type littermates during sinusoidal optokinetic stimulation. Both SS and CS discharge dynamics appeared to be very similar in wild-type and transgenic P-cells at all stimulus frequencies (0.05-0.8 Hz). The CS activity of all vertical axis cells increased with contralateral stimulus rotation and lagged ipsiversive eye velocity by 165-180 degrees. The SS modulation was roughly reciprocal to the CS modulation and lagged ipsiversive eye velocity by approximately 15 degrees. The baseline SS and CS discharge characteristics were indistinguishable between the two genotypes. We conclude that the impaired VOR learning in L7-PKCI mutants does not reflect fundamental aberrations of the cerebellar circuitry. The data thus strengthen the evidence that cerebellar LTD is implicated in rapid VOR learning but not in the development of normal default response patterns.
机译：平行纤维-Purkinje细胞（P细胞）突触处的小脑长期抑郁症（LTD）被认为体现了神经元信息存储以进行运动学习。小脑LTD被选择性阻滞的转基因L7蛋白激酶C抑制剂（PKCI）小鼠确实表现出前庭眼反射（VOR）的适应性受损，而其默认动眼功能却不受影响。尽管有支持作用，但这些数据并不能最终确定运动学习所需的记忆存储与小脑LTD之间的因果关系。由于L7-PKCI转基因可能是从P细胞发育的早期阶段就激活的，因此，另一种选择可能是P细胞在L7-PKCI突变体中产生异常信号，从而干扰了依赖于适当P细胞输出的运动学习机制。为了验证这一替代假设，我们研究了正弦光动能刺激期间L7-PKCI小鼠及其野生型同窝动物的小球中垂直轴P细胞的简单峰值（SS）和复杂峰值（CS）活性。在所有刺激频率（0.05-0.8 Hz）下，野生型和转基因P细胞的SS和CS放电动力学都非常相似。随着对侧刺激旋转，所有纵轴细胞的CS活性增加，并且渐进眼速度降低了165-180度。 SS调制与CS调制大致成反比，并且滞后的全眼速大约为15度。两种基因型之间的基线SS和CS放电特征没有区别。我们得出的结论是，L7-PKCI突变体中受损的VOR学习不能反映小脑回路的基本畸变。因此，数据加强了小脑LTD参与快速VOR学习但不参与正常默认应答模式发展的证据。

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