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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Pyramidal neurons of upper cortical layers generated by NEX-positive progenitor cells in the subventricular zone.
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Pyramidal neurons of upper cortical layers generated by NEX-positive progenitor cells in the subventricular zone.

机译：皮层下区域的NEX阳性祖细胞产生的上皮层锥体神经元。

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摘要

The generation of pyramidal neurons in the mammalian neocortex has been attributed to proliferating progenitor cells within the ventricular zone (VZ). Recently, the subventricular zone (SVZ) has been recognized as a possible source of migratory neurons in brain slice preparations, but the relevance of these observations for the developing neocortex in vivo remains to be defined. Here, we demonstrate that a subset of progenitor cells within the SVZ of the mouse neocortex can be molecularly defined by Cre recombinase expression under control of the NEX/Math2 locus, a neuronal basic helix-loop-helix gene that by itself is dispensable for cortical development. NEX-positive progenitors are generated by VZ cells, move into the SVZ, and undergo multiple asymmetrical and symmetrical cell divisions that produce a fraction of the neurons in the upper cortical layers. Our data suggest that NEX-positive progenitors within the SVZ are committed to a glutamatergic neuronal fate and have evolved to expand the number of cortical output neurons that is characteristic for the mammalian forebrain.
机译：哺乳动物新皮层中锥体神经元的产生已归因于心室区（VZ）中增殖的祖细胞。近来，脑室下区域（SVZ）已被认为是脑切片制剂中迁移神经元的可能来源，但是这些观察结果与体内新皮层发育的相关性仍有待确定。在这里，我们证明了小鼠新皮层SVZ内的祖细胞子集可以在NEX / Math2基因座的控制下，通过Cre重组酶表达进行分子定义，NEX / Math2基因座是神经元基本螺旋-环-螺旋基因，其本身对于皮层是必不可少的发展。 NEX阳性祖细胞由VZ细胞生成，移入SVZ，并经历多个不对称和对称的细胞分裂，在上皮层中产生一部分神经元。我们的数据表明，SVZ中的NEX阳性祖细胞致力于谷氨酸能神经元的命运，并已进化为扩大哺乳动物前脑所特有的皮质输出神经元的数量。

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