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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Genetics and genomics of Drosophila mating behavior
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Genetics and genomics of Drosophila mating behavior

机译：果蝇交配行为的遗传学和基因组学

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摘要

The first steps of animal speciation are thought to be the development of sexual isolating mechanisms. In contrast to recent progress in understanding the genetic basis of postzygotic isolating mechanisms, little is known about the genetic architecture of sexual isolation. Here, we have subjected Drosophila melanogaster to 29 generations of replicated divergent artificial selection for mating speed. The phenotypic response to selection was highly asymmetrical in the direction of reduced mating speed, with estimates of realized heritability averaging 7%. The selection response was largely attributable to a reduction in female receptivity. We assessed the whole genome transcriptional response to selection for mating speed using Affymetrix GeneChips and a rigorous statistical analysis. Remarkably, >3,700 probe sets (21% of the array elements) exhibited a divergence in message levels between the Fast and Slow replicate lines. Genes with altered transcriptional abundance in response to selection fell into many different biological process and molecular function Gene Ontology categories, indicating substantial pleiotropy for this complex behavior. Future functional studies are necessary to test the extent to which transcript profiling of divergent selection lines accurately predicts genes that directly affect the selected trait.
机译：动物物种形成的第一步被认为是性隔离机制的发展。与了解合子后隔离机制的遗传基础的最新进展相反，对性隔离的遗传结构了解甚少。在这里，我们对果蝇进行了29代重复发散的人工选择，以提高交配速度。对选择的表型反应在降低交配速度的方向上是高度不对称的，估计的遗传力平均为7％。选择反应主要归因于女性接受能力的下降。我们使用Affymetrix GeneChips和严格的统计分析评估了对选择交配速度的全基因组转录反应。值得注意的是，> 3,700个探针组（占阵列元素的21％）在快速和慢速复制线之间显示出不同的消息水平。响应选择而改变了转录丰度的基因分为许多不同的生物学过程和分子功能基因本体论类别，表明这种复杂行为的实质性多效性。未来的功能研究对于测试不同选择系的转录谱分析准确预测直接影响所选性状的基因的程度是必要的。

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