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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >ELG1, a regulator of genome stability, has a role in telomere length regulation and in silencing
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ELG1, a regulator of genome stability, has a role in telomere length regulation and in silencing

机译：ELG1是基因组稳定性的调节剂，在端粒长度调节和沉默中起作用

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摘要

Telomeres, the natural ends of eukaryotic chromosomes, prevent the loss of chromosomal sequences and preclude their recognition as broken DNA. Telomere length is kept under strict boundaries by the action of various proteins, some with negative and others with positive effects on telomere length. Recently, data have been accumulating to support a role for DNA replication in the control of telomere length, although through a currently poorly understood mechanism. Elg1p, a replication factor C (RFC)-like protein of yeast, contributes to genome stability through a putative replication-associated function. Here, we show that Elg1p participates in negative control of telomere length and in telomeric silencing through a replication-mediated pathway. We show that the telomeric function of Elg1 is independent of recombination and completely dependent on an active telomerase. Additionally, this function depends on yKu and DNA polymerase. We discuss alternative models to explain how Elg1p affects telomere length.
机译：端粒是真核染色体的天然末端，可防止染色体序列的丢失并阻止其识别为断裂的DNA。端粒长度受各种蛋白质的作用限制在严格的范围内，某些对端粒长度具有负面影响，而另一些则具有正面影响。近来，尽管通过目前知之甚少的机制，但仍在积累数据以支持DNA复制在端粒长度控制中的作用。 Elg1p是一种类似于酵母的复制因子C（RFC）的蛋白质，通过假定的复制相关功能有助于基因组稳定性。在这里，我们显示Elg1p通过复制介导的途径参与端粒长度的负控制和端粒沉默。我们显示Elg1的端粒功能独立于重组，并且完全依赖于活性端粒酶。此外，此功能取决于yKu和DNA聚合酶。我们讨论替代模型来解释Elg1p如何影响端粒长度。

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