...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Identification of a prostate cancer susceptibility locus on chromosome 7q11-21 in Jewish families
【24h】

Identification of a prostate cancer susceptibility locus on chromosome 7q11-21 in Jewish families

机译：犹太家庭中染色体7q11-21上的前列腺癌易感基因座的鉴定

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Results from over a dozen prostate cancer susceptibility genome-wide scans, encompassing some 1,500 hereditary prostate cancer families, indicate that prostate cancer is an extremely heterogeneous disease with multiple loci contributing to overall susceptibility. In an attempt to reduce locus heterogeneity, we performed a genomewide linkage scan for prostate cancer susceptibility genes with 36 Jewish families, which represent a stratification of hereditary prostate cancer families with potentially increased locus homogeneity. The 36 Jewish families represent a combined dataset of 17 Jewish families from the Fred Hutchinson Cancer Research Center-based Prostate Cancer Genetic Research Study dataset and 19 Ashkenazi Jewish families collected at Johns Hopkins University. All available family members, including 94 affected men, were genotyped at markers distributed across the genome with an average interval of <10 centimorgans. Nonparametric multipoint linkage analyses were the primary approach, although parametric analyses were performed as well. Our strongest signal was a significant linkage peak at 7q11-21, with a nonparametric linkage (NPL) score of 3.01 (P = 0.0013). Simulations indicated that this corresponds to a genornewide empirical P = 0.006. All other regions had NPL P values ≥0.02. After genotyping additional markers within the 7q11-21 peak, the NPL score increased to 3.35 (P= 0.0004) at D7S634 with an allele-sharing logarithm of odds of 3.12 (P = 0.00007). These studies highlight the utility of analyzing defined sets of families with a common origin for reducing locus heterogeneity problems associated with studying complex traits.
机译：来自十几个前列腺癌易感性全基因组扫描的结果涵盖了约1,500个遗传性前列腺癌家族，表明前列腺癌是一种极其异质的疾病，多个基因座对整体易感性有贡献。为了减少基因座异质性，我们对36个犹太人家族的前列腺癌易感基因进行了全基因组连锁扫描，这代表了可能增加基因座同质性的遗传性前列腺癌家族的分层。这36个犹太家庭代表了基于弗雷德·哈钦森癌症研究中心的前列腺癌基因研究数据集的17个犹太家庭和约翰·霍普金斯大学收集的19个阿什肯纳兹犹太家庭的组合数据集。所有可用的家庭成员，包括94名受影响的男性，均在基因组中分布的标记上进行基因分型，平均间隔<10厘摩。非参数多点链接分析是主要方法，尽管也执行了参数分析。我们最强的信号是在7q11-21处有一个显着的连锁峰，非参数连锁（NPL）得分为3.01（P = 0.0013）。模拟表明，这对应于genornewide经验P = 0.006。所有其他区域的NPL P值均≥0.02。对7q11-21峰内的其他标记进行基因分型后，D7S634的NPL得分增加到3.35（P = 0.0004），等位基因共享对数的对数为3.12（P = 0.00007）。这些研究突显了分析具有共同起源的特定家庭集合的实用性，以减少与研究复杂性状相关的基因座异质性问题。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号