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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire
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Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire

机译：自发增殖，由记忆细胞库的多样性决定的幼稚CD4 T细胞的反应

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摘要

T cell numbers are maintained within narrow ranges in vivo. introduction of naive cells into lymphopenic environments results in proliferation and differentiation driven by the recognition of peptide/MHC complexes and by cytokine signaling. This process, often described as homeostatic proliferation, is here referred to as spontaneous proliferation. We show that, although the presence of memory CD4 T cells of broad repertoire efficiently inhibits proliferation/differentiation of naive CD4 T cells, a memory population of similar size comprised of cells with a repertoire of limited diversity fails to do so, implying that cells of a given specificity prevent responses of cells of the same or related specificity. This finding suggests that the immune system has evolved mechanisms to attain a memory cell repertoire of great diversity independently of foreign antigens. [References: 33]
机译：T细胞数量在体内维持在狭窄范围内。将幼稚细胞引入淋巴细胞减少环境会导致增殖和分化，这是由肽/ MHC复合物的识别以及细胞因子信号传导驱动的。此过程通常称为稳态增殖，在此称为自发增殖。我们表明，尽管广泛的记忆CD4 T细胞的存在可以有效地抑制幼稚CD4 T细胞的增殖/分化，但是由具有有限多样性的细胞组成的具有相似大小的记忆种群却无法做到这一点，这暗示着给定的特异性会阻止具有相同或相关特异性的细胞的反应。该发现表明，免疫系统已经进化出机制，以获得独立于外来抗原的高度多样性的记忆细胞库。 [参考：33]

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