...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Coincidence detection enhances appropriate wiring of the nervous system
【24h】

Coincidence detection enhances appropriate wiring of the nervous system

机译：巧合检测可增强神经系统的适当布线

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Understanding how the spectacular complexity of connections among the neurons in the brain is established during embryonic development often is referred to as "the wiring problem." Wiring assembly is viewed largely as a two-stage operation, involving axon pathfinding to reach the target and target selection that enables formation of appropriate synaptic connections (1, 2). The former entails growth cone migration that can occur over substantial distances and is considered to be driven largely by molecular cues; electrical activity is thought to play little role, with some exceptions (3, 4). The latter, involving sorting of axons in local regions, has been shown to involve electrical activity. Blocking action potentials with tetrodotoxin that plugs voltage-gated sodium channels leads to defects in the precision of synaptic connections (5). In a recent issue of PNAS, Kasyanov et al. (6) reported the function of a different form of excitability in the establishment of functional connections in the hippocampus, a region of the brain known to be important for the formation of declarative memories. These new findings include identification of the function in the developing brain of a well described form of embryonic excitability, giant depolarizing potentials (GDPs; refs. 7 and 8), and illustrate a role for calcium signaling in synapse formation. The results also show that coincidence detection, long appreciated to play a role in strengthening synaptic connections in mature and developing nervous systems (9-11), can be important for establishing synaptic connections during embryogenesis.
机译：理解在胚胎发育过程中如何建立大脑神经元之间连接的惊人复杂性通常被称为“接线问题”。接线组装在很大程度上被视为两阶段操作，涉及轴突寻路以达到目标和目标选择，从而能够形成适当的突触连接（1、2）。前者导致生长锥迁移，该迁移锥可能发生在相当长的距离上，并且被认为主要是由分子线索驱动的。除了某些例外，人们认为电活动起的作用很小（3、4）。后者涉及在局部区域中对轴突的分类，已被证明涉及电活动。河豚毒素阻断电压门控钠通道的动作电位可能导致突触连接精度的缺陷（5）。在最近一期的PNAS中，Kasyanov等人。 （6）报道了在海马功能连接的建立过程中，不同形式的兴奋性的功能。海马是已知对声明性记忆形成很重要的区域。这些新发现包括以发育良好的形式描述胚胎兴奋性，巨大的去极化潜力（GDP；参考文献7和8），并说明钙信号在突触形成中的作用。结果还表明，巧合检测长期以来被认为在加强成熟和发育中的神经系统中的突触连接中发挥作用（9-11），对于在胚胎发生过程中建立突触连接很重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号