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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Physical and functional association of RNA polymerase II and the proteasome
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Physical and functional association of RNA polymerase II and the proteasome

机译：RNA聚合酶II与蛋白酶体的物理和功能关联

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摘要

Recent studies from a number of laboratories have revealed a surprising number of connections between RNA polymerase 11 transcription and the ubiquitin/proteasome pathway. We now find yet another intersection of these pathways by showing that the 26S proteasome associates with regions of the GAL1, GAL10, and HSP82 genes, including the 3' ends, in a transcription-dependent fashion. The appearance of the proteasome on these inducible genes correlates with both the accumulation of transcripts and the buildup of RNA polymerase 11 complexes in the same region. Furthermore, the 26S proteasome and RNA polymerase 11 coimmunoprecipitate, and inhibition of 26S proteolytic activity leads to increased read through of a transcription termination site. We suggest that the proteasome is generally recruited to the DNA at sites of stalled RNA polymerase and may act to resolve these complexes.
机译：来自许多实验室的最新研究表明，RNA聚合酶11转录与泛素/蛋白酶体途径之间的连接数量惊人。现在，我们通过显示26S蛋白酶体以转录依赖的方式与GAL1，GAL10和HSP82基因的区域（包括3'末端）相关联，发现了这些途径的另一个交叉点。蛋白酶体在这些可诱导基因上的出现与转录物的积累和同一区域中RNA聚合酶11复合物的积累相关。此外，26S蛋白酶体和RNA聚合酶11发生共沉淀，而26S蛋白水解活性的抑制导致转录终止位点的通读增加。我们建议蛋白酶体通常在停滞的RNA聚合酶位点被募集到DNA中，并可能起到解决这些复合物的作用。

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