...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Suppression of caspase-8-and-10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth
【24h】

Suppression of caspase-8-and-10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth

机译：caspase-8和10相关的RING蛋白的抑制导致对死亡配体的致敏并抑制肿瘤细胞的生长

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The destruction of cellular targets during apoptosis is carried out by caspases, which are negatively regulated by the inhibitor of apoptosis proteins (IAP); however, death effector domain (DED) caspases of the extrinsic pathway are refractory to the IAP family. We have isolated a family of apoptotic inhibitors [caspases-8- and -10-associated RING proteins (CARPs)] that bind to and negatively regulate DED caspases. When overexpressed, CARPs, via an IAP-like RING domain, can contribute to the ubiquitin-mediated proteolysis of DED caspases. Furthermore, CARPs are rapidly cleaved during apoptosis. However, in tumors and tumor cell lines, they are overexpressed, and their silencing leads to restoration of efficient apoptosis via enhanced activation of DED caspases. Long-term inhibition of CARP expression results in suppression of cancer cell growth, highlighting their importance in tumor cell survival.
机译：凋亡过程中细胞靶标的破坏是由胱天蛋白酶引起的，胱天蛋白酶由凋亡蛋白抑制剂（IAP）负调节。但是，外部途径的死亡效应域（DED）胱天蛋白酶对IAP家族是难治的。我们已经分离出一系列凋亡抑制剂[caspases-8和-10-相关的RING蛋白（CARPs）]，它们与DED caspases结合并对其产生负调控。当过表达时，CARPs通过IAP样RING域可以促进泛素介导的DED半胱天冬酶蛋白水解。此外，在凋亡过程中，CARPs被迅速裂解。然而，在肿瘤和肿瘤细胞系中，它们过表达，并且其沉默通过增强DED胱天蛋白酶的活化导致有效的细胞凋亡的恢复。长期抑制CARP表达可抑制癌细胞的生长，突出了它们在肿瘤细胞存活中的重要性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号