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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Heterochromatin on the inactive X chromosome delays replication timing without affecting origin usage
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Heterochromatin on the inactive X chromosome delays replication timing without affecting origin usage

机译：非活性X染色体上的异染色质可延迟复制时间，而不会影响来源使用

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摘要

DNA replication origins (ORIs) map close to promoter regions in many organisms, including mammals. However, the relationship between initiation of replication and transcription is not well understood. To address this issue, we have analyzed replication timing and activity of several CpG island-associated ORIs on the transcriptionally active and silent X chromosomes. We find equivalent ORI usage and efficiency of both alleles at sites that are replicated late on the inactive X chromosome. Thus, in contrast to its repressive effect on transcription, heterochromatin does not influence ORI activity. These findings suggest that the relationship between sites of transcription and replication initiation at CpG island regions is restricted to early development, and that subsequent gene silencing and heterochromatin formation influence only the timing of ORI activation.
机译：DNA复制起点（ORIs）在许多生物（包括哺乳动物）中都靠近启动子区域。但是，复制起始与转录之间的关系尚不十分清楚。为了解决这个问题，我们分析了几个CpG岛相关ORI在转录活跃和沉默X染色体上的复制时间和活性。我们发现非等位X染色体后期复制的两个等位基因的ORI用法和效率均相等。因此，与其对转录的抑制作用相反，异染色质不影响ORI活性。这些发现表明，CpG岛区域转录和复制起始位点之间的关系仅限于早期发育，随后的基因沉默和异染色质形成仅影响ORI激活的时间。

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