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首页> 外国专利> A method for preparing cell lines that have artificial chromosomes, uses thereof and methods for preparing artificial chromosomes in particular they are satellite artificial chromosomes that are composed of heterochromatin and the inserted heterologous DNA

A method for preparing cell lines that have artificial chromosomes, uses thereof and methods for preparing artificial chromosomes in particular they are satellite artificial chromosomes that are composed of heterochromatin and the inserted heterologous DNA

机译：制备具有人工染色体的细胞系的方法，其用途和制备人工染色体的方法，特别是它们是由异染色质和插入的异源DNA组成的卫星人工染色体

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The specification describes the preparation of artificial chromosomes, in particular, isolated substantially pure satellite artificial chromosomes. Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. In particular, satellite artificial chromosomes that, except for inserted heterologous DNA, are substantially composed of heterochromatin, are provided. Methods for use of the artificial chromosomes, including for gene therapy, production of gene products and production of transgenic plants and animals are also provided.
机译：该说明书描述了人工染色体的制备，特别是分离的基本上纯净的卫星人工染色体。提供了用于制备包含人工染色体的细胞系的方法，用于人工染色体的制备的方法，用于纯化人工染色体的方法，用于将异源DNA定向插入人工染色体中的方法以及用于将染色体递送至所选细胞和组织的方法。还提供了用于该方法的细胞系，以及通过该方法产生的细胞系和染色体。特别地，提供了卫星人工染色体，其除了插入的异源DNA外，基本上由异染色质组成。还提供了使用人工染色体的方法，包括用于基因治疗，基因产物的生产以及转基因植物和动物的生产。

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