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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Nanos suppresses somatic cell fate in Drosophila germ line.
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Nanos suppresses somatic cell fate in Drosophila germ line.

机译：Nanos抑制果蝇种系中的体细胞命运。

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摘要

Nanos (Nos) is one of the evolutionarily conserved proteins known to direct germ-line development. In Drosophila, maternal Nos protein maintains transcriptional quiescence in the germ-line progenitors or pole cells to repress ectopic expression of somatic genes. Here we show that maternal Nos is required to establish and maintain germ-line identity by preventing apoptosis and somatic cell fate. The pole cells lacking maternal Nos were degraded by apoptosis during mid to late embryogenesis. When apoptosis was suppressed by Df(3L)H99, some pole cells lacking Nos adopted somatic cell fates. These pole cells expressed somatic markers ectopically and lost the germ-line marker Vasa. We further found that some Nos-negative pole cells were able to migrate into the gonads, but they failed to develop as functional germ cells during postembryonic stages. We propose a model in which Nos establishes germ-line/soma dichotomy and is also required to maintain germ-line fate.
机译：Nanos（Nos）是已知可指导种系发育的进化保守蛋白之一。在果蝇中，母体Nos蛋白在种系祖细胞或极细胞中保持转录静止，从而抑制体细胞基因的异位表达。在这里，我们表明，通过防止细胞凋亡和体细胞命运，建立和维持种系同一性需要母体Nos。缺乏母体Nos的极细胞在胚胎发生的中晚期被凋亡所降解。当Df（3L）H99抑制细胞凋亡时，一些缺乏Nos的极细胞采用了体细胞命运。这些极细胞在异位表达体细胞标志物，并失去种系标志物瓦萨。我们进一步发现，一些Nos阴性极细胞能够迁移到性腺中，但在胚胎后阶段却无法发育为功能性生殖细胞。我们提出了一个模型，其中Nos建立了种系/体的二分法，并且还需要这种模型来维持种系的命运。

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