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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A demonstration and findings of a statistical approach through reanalysis of inflammatory bowel disease data.
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A demonstration and findings of a statistical approach through reanalysis of inflammatory bowel disease data.

机译：通过对炎症性肠病数据的重新分析，证明了一种统计方法的发现。

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We test the backward haplotype transmission association algorithm on genome-scan data previously studied by Rioux et al. [Rioux, J. D., et al. (2000) Am. J. Hum. Genet. 66, 1863-1870]. In their study, multipoint linkage methods were applied to affected sib-pairs with inflammatory bowel disease, and significant linkage evidence points to two susceptibility loci. After we apply our approach to these data with a global search accounting for both joint and marginal effects, very interesting results emerge, many of them intriguing. These results provide compelling support for the application of our approach to other data wherever applicable. Results from this project also make it clear that it is important to reinvestigate available family-based datasets that can be suitably reanalyzed. Given previously collected data in the literature, our approach, with its increased efficiency in using available resources, draws additional crucial information that may lead to novel and surprising results.
机译：我们在先前由Rioux等人研究的基因组扫描数据上测试了反向单倍型传播关联算法。 [Rioux，J.D。等人。 （2000）上午J.哼基因66，1863-1870]。在他们的研究中，多点连锁法被应用于患有炎症性肠病的同胞对，重要的连锁证据指向两个易感基因座。在通过对联合和边际效应的全局搜索将我们的方法应用于这些数据之后，出现了非常有趣的结果，其中许多有趣。这些结果在适用的情况下为我们的方法应用于其他数据提供了有力的支持。该项目的结果也清楚表明，对可适当重新分析的基于家庭的可用数据集进行重新调查非常重要。给定先前文献中收集的数据，我们的方法以其在利用可用资源方面的更高效率而获得了更多关键信息，这些信息可能导致新颖而令人惊讶的结果。

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