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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Metastatic cancer DNA phenotype identified in normal tissues surrounding metastasizing prostate carcinomas.
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Metastatic cancer DNA phenotype identified in normal tissues surrounding metastasizing prostate carcinomas.

机译：在转移性前列腺癌周围的正常组织中鉴定出转移性癌症DNA表型。

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摘要

Fourier transform-infrared statistical models have the proven ability to identify subtle structural changes in DNA at various stages of tumor development. Using these models, we show evidence for a metastatic cancer DNA phenotype in histologically normal prostate tissues surrounding metastasizing tumors. Strikingly, the DNA base and backbone structures of the metastatic phenotype are indistinguishable from those of the metastasizing prostate tumors but distinctly different from the structure recently reported for the primary cancer DNA phenotype. These findings suggest that the DNA structure linked to the development of metastasis is preordained in progenitor cells relatively early in multistep tumorigenesis. The substantial structural differences found between the primary and metastatic cancer DNA phenotypes suggest that each evolves through a separate pathway. The metastatic phenotype is potentially an early predictor of metastatic disease. Interventions that inhibit its formation would be expected to also inhibit the development of metastatic tumors.
机译：傅里叶变换红外统计模型具有在肿瘤发展的各个阶段识别DNA细微结构变化的可靠能力。使用这些模型，我们显示了转移性肿瘤周围组织学正常的前列腺组织中转移性癌症DNA表型的证据。令人惊讶的是，转移表型的DNA碱基和骨架结构与转移性前列腺肿瘤的DNA碱基和骨架结构没有区别，但与最近报道的原发癌DNA表型的结构明显不同。这些发现表明与转移发展有关的DNA结构在多步骤肿瘤发生中相对较早地在祖细胞中被预先确定。在原发性和转移性癌症DNA表型之间发现的实质性结构差异表明，每种表型均通过单独的途径进化。转移表型可能是转移性疾病的早期预测指标。预期抑制其形成的干预也将抑制转移性肿瘤的发展。

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