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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Resolution of the insect ouabain paradox
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Resolution of the insect ouabain paradox

机译：昆虫哇巴因悖论的解决

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摘要

Many insects are highly resistant to plant toxins, such as the cardiac glycoside ouabain. How can the epithelia that must handle such toxins, also be refractory to them? In Drosophila, the Malpighian (renal) tubule contains large amounts of Na+,K+ ATPase that is known biochemically to be exquisitely sensitive to ouabain, yet the intact tissue is almost unaffected by even extraordinary concentrations. The explanation is that the tubules are protected by an active ouabain transport system, colocated with the Na+,K+ ATPase, thus preventing ouabain from reaching inhibitory concentrations within the basolateral infoldings of principal cells. These data show that the Na+,K+ ATPase, previously thought to be unimportant, may be as vital in insect tissues as in vertebrates, but can be cryptic to conventional pharmacology.
机译：许多昆虫对植物毒素（例如强心苷哇巴因）具有很高的抵抗力。必须处理这种毒素的上皮又如何对它们具有抵抗力？在果蝇中，Malpighian（肾）肾小管含有大量的Na +，K + ATPase，从生化角度来看，它们对哇巴因非常敏感，但是完整的组织几乎不受甚至超高浓度的影响。解释是，小管受到活跃的哇巴因转运系统的保护，该系统与Na +，K + ATPase并置，从而防止哇巴因在主要细胞的基底外侧折叠中达到抑制浓度。这些数据表明，以前认为不重要的Na +，K + ATPase在昆虫组织中的重要性与在脊椎动物中一样重要，但对常规药理学可能是神秘的。

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