...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Fusogenic supramolecular vesicle systems induced by metal ion binding to amphiphilic ligands
【24h】

Fusogenic supramolecular vesicle systems induced by metal ion binding to amphiphilic ligands

机译：金属离子与两亲配体结合诱导的融合超分子囊泡系统

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The incorporation of lipophilic ligands into the bilayer membrane of vesicles offers the possibility to induce, upon binding of suitable metal ions, a variety of processes, in particular vesicle aggregation and fusion and generation of vesicle arrays, under the control of specific metal-ligand recognition events. Synthetic bipyridine lipoligands Bn bearing a bipyridine unit as head group were prepared and incorporated into large unilamellar vesicles. The addition of Ni2+ or Co2+ metal ions led to the formation of complexes MBn and MBn2 followed by spontaneous fusion to generate giant multilamellar vesicles. The metal ion complexation was followed by UV spectroscopy and the progressive fusion could be visualized by optical dark-field and fluorescence microscopies. Vesicle fusion occurred without leakage of the aqueous compartments and resulted in the formation of multilamellar giant vesicles because of the stacking of the lipoligands Bn. The fusion process required a long enough oligoethylene glycol spacer and a minimal concentration of lipoligand within the vesicle membrane. Metallosupramolecular systems such as the present one offer an attractive way to induce selective intervesicular processes, such as vesicle fusion, under the control of molecular recognition between specific metal ions and lipoligands incorporated in the bilayer membrane. They provide an approach to the design of artificial "tissue-mimetics" through the generation of polyvesicular arrays of defined architecture and to the control of their functional properties.
机译：将亲脂性配体掺入囊泡的双层膜中提供了一种可能性，即在合适的金属离子结合后，在特定的金属配体识别的控制下，诱导了多种过程，特别是囊泡的聚集和融合以及囊泡阵列的产生。事件。制备具有联吡啶单元作为头部基团的合成联吡啶脂质配体Bn，并将其掺入大的单层囊泡中。 Ni2 +或Co2 +金属离子的添加​​导致形成复合物MBn和MBn2，然后自发融合以生成巨大的多层囊泡。金属离子络合之后是紫外光谱，通过光学暗场和荧光显微镜可以观察到逐步融合。囊泡融合发生而没有水室的渗漏，并且由于脂质配体Bn的堆积而导致了多层巨囊泡的形成。融合过程需要足够长的低聚乙二醇间隔基和囊泡膜中最小的脂配体浓度。诸如本发明的金属超分子系统提供了一种诱人的方式，以在结合在双层膜中的特定金属离子和脂配体之间的分子识别的控制下，诱导选择性的囊泡间过程，例如囊泡融合。它们通过产生定义结构的多囊泡阵列并控制其功能特性，为人造“组织模拟物”的设计提供了一种方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号