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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit
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Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit

机译：喂食状态和5-羟色胺快速可逆地调节秀丽隐杆线虫的化学感觉回路

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摘要

Serotonin (5-HT) modulates synaptic efficacy in the nervous system of vertebrates and invertebrates. In the nematode Caenorhabditis elegans, many behaviors are regulated by 5-HT levels, which are in turn regulated by the presence or absence of food. Here, we show that both food and 5-HT signaling modulate chemosensory avoidance response of octanol in C. elegans, and that this modulation is both rapid and reversible. Sensitivity to octanol is decreased when animals are off food or when 5-HT levels are decreased; conversely, sensitivity is increased when animals are on food or have increased 5-HT signaling. Laser microsurgery and behavioral experiments reveal that sensory input from different subsets of octanol-sensing neurons is selectively used, depending on stimulus strength, feeding status, and 5-HT levels. 5-HT directly targets at least one pair of sensory neurons, and 5-HT signaling requires the Galpha protein GPA-11. Glutamatergic signaling is required for response to octanol, and the GLR-1 glutamate receptor plays an important role in behavioral response off food but not on food. Our results demonstrate that 5-HT modulation of neuronal activity via G protein signaling underlies behavioral plasticity by rapidly altering the functional circuitry of a chemosensory circuit.
机译：5-羟色胺（5-HT）调节脊椎动物和无脊椎动物神经系统的突触功效。在线虫秀丽隐杆线虫中，许多行为受5-HT水平调节，而5-HT水平又受食物存在或不存在的调节。在这里，我们表明食物和5-HT信号均可以调节秀丽隐杆线虫中辛醇的化学感应回避反应，并且这种调节既快速又可逆。当动物断食或降低5-HT水平时，对辛醇的敏感性降低；相反，当动物在食物上或具有增加的5-HT信号传导时，敏感性会增加。激光显微外科手术和行为实验表明，根据刺激强度，进食状态和5-HT水平，选择性地使用了来自辛醇敏感神经元不同子集的感觉输入。 5-HT直接靶向至少一对感觉神经元，而5-HT信号传导则需要Galpha蛋白GPA-11。对辛醇的反应需要谷氨酸能信号传导，而GLR-1谷氨酸受体在食物以外的行为反应中起着重要的作用，而对食物没有作用。我们的研究结果表明，通过G蛋白信号传导对神经元活性进行5-HT调节可通过快速改变化学感应电路的功能电路来为行为可塑性奠定基础。

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