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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Dysregulation of the fibroblast growth factor system in major depression
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Dysregulation of the fibroblast growth factor system in major depression

机译：重度抑郁症中的成纤维细胞生长因子系统异常

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摘要

In this report we describe findings that imply dysregulation of several fibroblast growth factor (FGF) system transcripts in frontal cortical regions of brains from human subjects with major depressive disorder (MDD). This altered gene expression was discovered by microarray analysis of frontal cortical tissue from MDD, bipolar, and nonpsychiatric control subjects and was verified by quantitative real-time PCR analysis and, importantly, in a separate cohort of MDD subjects. Furthermore, we show, through a separate analysis of specific serotonin reuptake inhibitor (SSRI)-treated and non-SSRI-treated MDD subjects that the observed changes in expression of FGF transcripts are not secondary to drug treatment. Rather, changes in specific FGF transcripts are attenuated by SSRIs and may thus be partially responsible for the mechanism of action of these drugs. We also make available the gene-expression profile of all of the other growth factors and growth factor receptors detected in these postmortem samples.
机译：在此报告中，我们描述了一些发现，这些发现暗示着患有严重抑郁症（MDD）的人的大脑额叶皮层区域中某些成纤维细胞生长因子（FGF）系统的转录异常。这种改变的基因表达是通过对MDD，双相性和非精神病性对照受试者的额叶皮层组织进行微阵列分析发现的，并通过实时定量PCR分析以及重要的是在MDD受试者的另一个队列中进行了验证。此外，我们通过对特定5-羟色胺再摄取抑制剂（SSRI）治疗和未SSRI治疗的MDD受试者的单独分析表明，观察到的FGF转录表达变化并非继发于药物治疗。而是，特定FGF转录物的变化被SSRI减弱，因此可能部分负责这些药物的作用机理。我们还提供了在这些尸检样品中检测到的所有其他生长因子和生长因子受体的基因表达谱。

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