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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The gut microbiota as an environmental factor that regulates fat storage.
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The gut microbiota as an environmental factor that regulates fat storage.

机译：肠道菌群是调节脂肪储存的环境因素。

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New therapeutic targets for noncognitive reductions in energy intake, absorption, or storage are crucial given the worldwide epidemic of obesity. The gut microbial community (microbiota) is essential for processing dietary polysaccharides. We found that conventionalization of adult germ-free (GF) C57BL/6 mice with a normal microbiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake. Studies of GF and conventionalized mice revealed that the microbiota promotes absorption of monosaccharides from the gut lumen, with resulting induction of de novo hepatic lipogenesis. Fasting-induced adipocyte factor (Fiaf), a member of the angiopoietin-like family of proteins, is selectively suppressed in the intestinal epithelium of normal mice by conventionalization. Analysis of GF and conventionalized, normal and Fiaf knockout mice established that Fiaf is a circulating lipoprotein lipase inhibitor and that its suppression is essential for the microbiota-induced deposition of triglycerides in adipocytes. Studies of Rag1-/- animals indicate that these host responses do not require mature lymphocytes. Our findings suggest that the gut microbiota is an important environmental factor that affects energy harvest from the diet and energy storage in the host.
机译：鉴于世界范围内的肥胖病流行，非认知性减少能量摄入，吸收或储存的新治疗目标至关重要。肠道微生物群落（微生物群）对于加工膳食多糖至关重要。我们发现，常规成年的无菌（GF）C57BL / 6小鼠与常规饲养动物的远端肠道（盲肠）收获的正常菌群进行常规饲养，尽管食物减少，但14天内其体内脂肪含量和胰岛素抵抗增加了60％录取。 GF和常规小鼠的研究表明，微生物群可促进肠道腔内单糖的吸收，从而诱导从头开始的肝脏脂肪生成。空腹诱导的脂肪细胞因子（Fiaf）是血管生成素样蛋白家族的成员，通过常规作用在正常小鼠的肠上皮中被选择性抑制。对GF和常规，正常和Fiaf基因敲除小鼠的分析证实，Fiaf是一种循环脂蛋白脂肪酶抑制剂，其抑制作用是微生物引起的甘油三酸酯在脂肪细胞中沉积所必需的。 Rag1-/-动物的研究表明，这些宿主反应不需要成熟的淋巴细胞。我们的发现表明，肠道菌群是一个重要的环境因素，会影响饮食中的能量收集和宿主体内的能量存储。

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