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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Activation of the complement system generates antibacterial peptides
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Activation of the complement system generates antibacterial peptides

机译：补体系统的激活产生抗菌肽

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摘要

The complement system represents an evolutionary old and significant part of the innate immune system involved in protection against invading microorganisms. Here, we show that the anaphylatoxin C3a and its inactivated derivative C3a-desArg are antibacterial, demonstrating a previously unknown direct antimicrobial effect of complement activation. The C3a peptide, as well as functional epitopes in the sequence, efficiently killed the Graml negative bacteria Escherichia coli, Pseudomonas aeruginosa, and the Gram-positive Enterococcus faecalis. In mice, a C3a-derived pepticle suppressed infection by Gram-positive Streptococcuspyogenes bacteria. Fluorescence and electron microscopy demonstrated that C3a binds to and induces breaks in bacterial membranes. C3a was also found to induce membrane leakage of liposomes. These findings provide an interesting link between the complement system and antimicrobial peptides, which are two important branches of innate immunity.
机译：补体系统代表先天免疫系统的进化古老和重要部分，涉及抵抗入侵微生物的保护。在这里，我们显示了过敏毒素C3a及其灭活的衍生物C3a-desArg具有抗菌作用，证明了补体激活的先前未知的直接抗菌作用。 C3a肽以及序列中的功能性表位有效杀死了革兰氏阴性细菌大肠杆菌，铜绿假单胞菌和革兰氏阳性肠球菌。在小鼠中，源自C3a的消化道抑制了革兰氏阳性链球菌致病菌的感染。荧光和电子显微镜显示，C3a结合并诱导细菌膜破裂。还发现C3a诱导脂质体的膜泄漏。这些发现提供了补体系统和抗菌肽之间的有趣联系，抗菌肽是先天免疫的两个重要分支。

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