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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Optimal ion channel clustering for intracellular calcium signaling.
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Optimal ion channel clustering for intracellular calcium signaling.

机译:用于细胞内钙信号传导的最佳离子通道聚类。

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摘要

Ion channels and receptors in the cell membranes and internal membranes are often distributed in discrete clusters. One particularly well-studied example is the distribution of inositol 1,4,5-triphosphate receptors in the plasma membrane that controls the flux of Ca2+ from the endoplasmic reticulum into the cytosol. By using mathematical modeling, we show that channel clustering can enhance the cell's Ca2+ signaling capability. Furthermore, we predict optimal signaling cellular capability at cluster sizes and distances that agree with experimentally found values in Xenopus oocyte.
机译:细胞膜和内膜中的离子通道和受体通常分布在离散的簇中。一个经过充分研究的实例是质膜中肌醇1,4,5-三磷酸受体的分布,它控制Ca2 +从内质网进入细胞质的流量。通过使用数学模型,我们表明通道聚类可以增强细胞的Ca2 +信号传导能力。此外,我们预测在群集大小和距离与非洲爪蟾卵母细胞中实验发现的值一致的最佳信号传导细胞能力。

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