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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >In vivo identification of human cortical areas using high-resolution MRI: an approach to cerebral structure-function correlation.
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In vivo identification of human cortical areas using high-resolution MRI: an approach to cerebral structure-function correlation.

机译：使用高分辨率MRI在体内识别人皮层区域：一种大脑结构与功能相关的方法。

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摘要

Understanding the relationship between the structural and functional organization of the human brain is one of the most important goals of neuroscience. Individual variability in brain structure means that it is essential to obtain this information from the same subject. To date, this has been almost impossible. Even though noninvasive functional imaging techniques such as functional MRI (fMRI) are now commonplace, there is no complementary noninvasive structural technique. We present an in vivo method of examining the detailed neuroanatomy of any individual, which can then be correlated with that individual's own functional results. This method utilizes high-resolution structural MRI to identify distinct cortical regions based on cortical lamination structure. We demonstrate that the observed MR lamination patterns relate to myeloarchitecture through a correlation of histology with MRI. In vivo high-resolution MRI studies identify striate cortex, as well as visual area V5, in four individuals, as defined by using fMRI. The anatomical identification of a cortical area (V5MT) outside of striate cortex is a significant advance, proving it possible to identify extra-striate cortical areas and demonstrating that in vivo structural mapping of the human cerebral cortex is possible.
机译：了解人脑的结构和功能组织之间的关系是神经科学的最重要目标之一。脑结构的个体可变性意味着从同一受试者获得此信息至关重要。迄今为止，这几乎是不可能的。即使无创功能成像技术（例如功能MRI（fMRI））现在很普遍，也没有互补的无创结构技术。我们提出了一种检查任何个体详细神经解剖的体内方法，然后可以将该方法与该个体自身的功能结果相关联。该方法利用高分辨率结构MRI来基于皮质层压结构识别不同的皮质区域。我们证明观察到的MR层压模式通过与MRI的组织学相关性与骨髓结构有关。体内高分辨率MRI研究确定了四个人的条纹皮质以及V5视区，这是使用fMRI定义的。纹状皮层外侧的皮质区域（V5MT）的解剖学识别是一项重大进步，证明有可能识别出纹状皮层以外的区域，并证明了人脑皮质的体内结构图绘制是可能的。

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