Control region mtDNA variants: Longevity, climatic adaptation, and a forensic conundrum

Pinar E. Coskun; Eduardo Ruiz-Pesini; Douglas C. Wallace

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Control region mtDNA variants: Longevity, climatic adaptation, and a forensic conundrum

机译：控制区mtDNA变体：寿命长，气候适应和法医难题

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Mitochondrial oxidative phos-phorylation (OXPHOS) has been observed to decline with age in association with the accumulation of somatic mtDNA rearrangement and base substitution mutations. These observations have lead to the theory that the mtDNA is the aging clock. To this aging story was added a new twist in a recent issue of PNAS, an mtDNA mutation that promotes longevity.

机译：线粒体氧化磷酸化（OXPHOS）已观察到随着年龄的增长而下降，这与体细胞mtDNA重排和碱基取代突变的积累有关。这些发现导致了理论，即mtDNA是衰老时钟。在这个衰老的故事中，最近一期的PNAS增加了新的转折，一种促进长寿的mtDNA突变。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2003年第5期|p.2174-2176|共3页
作者
Pinar E. Coskun; Eduardo Ruiz-Pesini; Douglas C. Wallace;
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作者单位

Center for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, CA 92692-3940;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. Control region mtDNA variants: Longevity climatic adaptation and a forensic conundrum [O] . Pinar E. Coskun, Eduardo Ruiz-Pesini, Douglas C. Wallace 2003

机译：控制区mtDNA变体：寿命长气候适应和法医难题
7. Control region mtDNA variants: Longevity, climatic adaptation, and a forensic conundrum [O] . Coskun, Pinar E., Ruiz-Pesini, Eduardo, Wallace, Douglas C. 2003

机译：控制区mtDNA变体：寿命长，气候适应和法医难题

Control region mtDNA variants: Longevity, climatic adaptation, and a forensic conundrum

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