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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies.
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Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies.

机译：Indy长寿命突变体果蝇的衰老与机体性能之间的条件折衷。

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摘要

Alterations that extend the life span of animals and yeast typically involve decreases in metabolic rate, growth, physical activity, andor early-life fecundity. This negative correlation between life span and the ability to assimilate and process energy, to move, grow, and reproduce, raises questions about the potential utility of life span extension. Tradeoffs between early-life fitness and longevity are central to theories of the evolution of aging, which suggests there is necessarily a price to be paid for reducing the rate of aging. It is not yet clear whether life span can be extended without undesirable effects on metabolism and fecundity. Here, we report that the long-lived Indy mutation in Drosophila causes a decrease in the slope of the mortality curve consistent with a slowing in the rate of aging without a concomitant reduction in resting metabolic rate, flight velocity, or age-specific fecundity under normal rearing conditions. However, Indy mutants on a decreased-calorie diet have reduced fecundity, suggesting that a tradeoff between longevity and this aspect of performance is conditional, i.e., the tradeoff can occur in a stressful environment while being absent in a more favorable environment. These results provide evidence that there do exist mechanisms, albeit conditional, that can extend life span without significant reduction in fecundity, metabolic rate, or locomotion.
机译：延长动物和酵母的寿命的改变通常涉及代谢率，生长，体育活动和/或早期生育力的降低。寿命与吸收和加工能量，移动，生长和繁殖的能力之间的这种负相关关系提出了有关延长寿命的潜在效用的问题。在寿命适应性和寿命之间的权衡是衰老进化理论的核心，这表明降低衰老率必须付出一定的代价。尚不清楚是否可以延长寿命而不对新陈代谢和繁殖力产生不良影响。在这里，我们报告果蝇中的长期印第突变导致死亡率曲线的斜率下降，这与衰老速率减慢一致，而在此条件下静息代谢率，飞行速度或特定年龄的繁殖力却没有随之降低。正常饲养条件。但是，低热量饮食中的Indy突变体的繁殖力降低，这表明长寿和性能方面之间的权衡是有条件的，即，权衡可以在压力环境中发生，而在更有利的环境中则不存在。这些结果提供了证据，尽管存在条件，但确实存在可以延长寿命而不会显着降低生育力，代谢率或运动的机制。

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