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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >An approach to electrical modeling of single and multiple cells.
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An approach to electrical modeling of single and multiple cells.

机译：对单个和多个单元进行电气建模的方法。

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摘要

Previous theoretical approaches to understanding effects of electric fields on cells have used partial differential equations such as Laplace's equation and cell models with simple shapes. Here we describe a transport lattice method illustrated by a didactic multicellular system model with irregular shapes. Each elementary membrane region includes local models for passive membrane resistance and capacitance, nonlinear active sources of the resting potential, and a hysteretic model of electroporation. Field amplification through current or voltage concentration changes with frequency, exhibiting significant spatial heterogeneity until the microwave range is reached, where cellular structure becomes almost electrically invisible. exhibits significant heterogeneity but occurs mostly at invaginations and cell layers with tight junctions. Such results involve emergent behavior and emphasize the importance of using multicellular models for understanding tissue-level electric field effects in higher organisms.
机译：先前了解电场对细胞影响的理论方法已经使用了偏微分方程，例如拉普拉斯方程和形状简单的细胞模型。在这里，我们描述了由不规则形状的有说服力的多细胞系统模型说明的传输格子方法。每个基本膜区域都包括用于被动膜电阻和电容的局部模型，静止电位的非线性主动源以及电穿孔的滞后模型。通过电流或电压集中进行的场放大会随频率变化，表现出明显的空间异质性，直到达到微波范围为止，在该范围内，细胞结构几乎变得不可见。表现出显着的异质性，但主要发生在接合处和紧密连接的细胞层。这些结果涉及新出现的行为，并强调了使用多细胞模型来理解高等生物中组织水平电场效应的重要性。

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