N-methyl-D-aspartate receptor blockade during development lowers long-term potentiation threshold without affecting dynamic range of CA3-CA1 synapses.

Savic N; Luthi A; Gahwiler BH; McKinney RA

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N-methyl-D-aspartate receptor blockade during development lowers long-term potentiation threshold without affecting dynamic range of CA3-CA1 synapses.

机译：在发育过程中，N-甲基-D-天冬氨酸受体的阻滞降低了长期增强阈值，而不会影响CA3-CA1突触的动态范围。

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摘要

During development, excitatory synapses in the CA1 region of the hippocampus undergo activity-dependent and N-methyl-d-aspartate (NMDA) receptor-dependent long-lasting changes in synaptic efficacy. These bidirectional changes occur between limits that determine the dynamic range within which synapses operate. It is unknown whether the dynamic range itself is also activity-dependent and NMDA receptor-dependent. Here, we show that chronic blockade of NMDA receptors in hippocampal slice cultures during early postnatal development does not affect the dynamic range but results in a lower threshold for the induction of long-term potentiation. Thus, the dynamic range of CA3-CA1 synapses, unlike long-term potentiation threshold, is NMDA receptor-independent, thereby providing functional stability to the hippocampal network during development.

机译：在发育过程中，海马CA1区的兴奋性突触在突触效力中经历活动依赖性和N-甲基-d-天冬氨酸（NMDA）受体依赖性持久变化。这些双向变化发生在确定突触工作范围的动态范围之间。尚不知道动态范围本身是否还依赖于活性和NMDA受体。在这里，我们表明，在产后早期发育过程中，海马切片培养物中对NMDA受体的慢性阻滞不会影响动态范围，但会导致较低的长期增强诱导阈值。因此，与长期增强阈值不同，CA3-CA1突触的动态范围与NMDA受体无关，从而在发育过程中为海马网络提供了功能稳定性。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2003年第9期|P.5503-5508|共6页
作者
Savic N; Luthi A; Gahwiler BH; McKinney RA;
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作者单位

Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
development aspects; Receptors; N-Methyl-D-Aspartate; aspartic acid receptor; 受体; N-甲基-D-天冬氨酸;

机译：development aspects;Receptors;N-Methyl-D-Aspartate;aspartic acid receptor;受体;N-甲基-D-天冬氨酸;

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1. Plasticity of synaptic GluN receptors is required for the Src-dependent induction of long-term potentiation at CA3-CA1 synapses. [J] . Li HB, Jackson MF, Yang K, Hippocampus . 2011,第10期

机译：突触的GluN受体的可塑性是CA3-CA1突触的Src依赖性长期增强的诱导所必需的。
2. Coexistence of muscarinic long-term depression with electrically induced long-term potentiation and depression at CA3-CA1 synapses. [J] . McCutchen E, Scheiderer CL, Dobrunz LE, Journal of Neurophysiology . 2006,第6期

机译：在CA3-CA1突触中，毒蕈碱长期抑制与电诱导的长期增强和抑制共存。
3. Long-term potentiation observed upon blockade of adenosine A1 receptors in rat hippocampus is N-methyl-D-aspartate receptor-dependent. [J] . de Mendonca-A, Ribeiro JA Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2000,第2期

机译：在大鼠海马中阻断腺苷A1受体后观察到的长期增强作用是N-甲基-D-天冬氨酸受体依赖性的。
4. Long-Term Potentiation and Ap: Targeting Ap Species, Cellular Mechanisms and Putative Receptors [C] . Michael J. Rowan, Igor Klyubin, William K. Cullen, Colloque me?decine et recherche . 2008

机译：长期增强和AP：靶向AP物种，细胞机制和推定受体
5. The Nitric Oxide (NO) Signaling Pathway Regulates Pre- and Postsynaptic Mechanisms Following Long-Term Potentiation (LTP) Induction at Thalamo-Amygdala Synapses. [D] . Ping, Junli. 2015

机译：一氧化氮（NO）信号通路调节丘脑-杏仁核突触的长期增强（LTP）诱导后的突触前和突触后机制。
6. N-methyl-d-aspartate receptor blockade during development lowers long-term potentiation threshold without affecting dynamic range of CA3-CA1 synapses [O] . Nataša Savić, Andreas Lüthi, Beat H. Gähwiler, 2003

机译：N-甲基-d-天冬氨酸受体在发育过程中的阻断降低了长期增强阈值而不影响CA3-CA1突触的动态范围
7. N-methyl-d-aspartate receptor blockade during development lowers long-term potentiation threshold without affecting dynamic range of CA3-CA1 synapses [O] . Savić, Nataša, Lüthi, Andreas, Gähwiler, Beat H., 2003

机译：N-甲基-d-天冬氨酸受体在发育过程中的阻断降低了长期增强阈值，而不影响CA3-CA1突触的动态范围
8. Persistent Increase of Hippocampal Presynaptic Axon Excitability After RepetitiveElectrical Stimulation: Dependence on N-Methyl-D-Aspartate Receptor Activity, Nitric-Oxide Synthase, and Temperature, (Quantal Analysts/Long-Term Potentiation/Neurophysiology [R] . McNaughton, B. L., Shen, J., Rao, G., 1994

机译：海马突触前轴突兴奋性持续上升RepetitiveElectrical刺激后：依赖是N-甲基d天冬氨酸受体活性，一氧化氮合酶，和温度（量子理论分析/长时程增强/神经生理学

N-methyl-D-aspartate receptor blockade during development lowers long-term potentiation threshold without affecting dynamic range of CA3-CA1 synapses.

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