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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Does clathrin pull the fission trigger?
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Does clathrin pull the fission trigger?

机译：网格蛋白会拉动裂变触发器吗？

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摘要

Clathrin-mediated vesicle budding is essential for a variety of intracellular membrane transport reactions in the secretory and endocytic pathways. This process can be dissected in several sequential steps that include the recruitment of the clathrin coat, membrane invagina-tion and concomitant propagation of the clathrin lattice, constriction of the vesicle neck, and finally fission of the coated vesicle, followed by its rapid un-coating. Although clathrin and clathrin adaptors, assisted by other accessory factors, drive this reaction up to the stage of a deeply invaginated coated pit, a distinct factor, the GTPase dy-namin, is thought to play a critical role in fission. To provide new clues concerning all sites where clathrin functions in mammalian cell physiology and on the vesicular traffic pathways that are dependent on clathrin, Iversen et al. (7) have engineered a mammalian cell line in which expression of clathrin can be suppressed by an inducible antisense RNA. Unexpectedly, this study has suggested a role for clathrin heavy chain in the regulation of dynamin expression and function.
机译：网格蛋白介导的囊泡出芽对于分泌和内吞途径中的多种细胞内膜转运反应至关重要。此过程可以分为几个顺序的步骤进行剖析，包括募集网格蛋白涂层，膜侵入和网格蛋白晶格伴随繁殖，囊泡颈部收缩，最后包被囊泡裂开，然后迅速解囊。涂层。尽管网格蛋白和网格蛋白衔接子在其他辅助因素的辅助下将这种反应驱动至深度浸染的包膜凹坑的阶段，但认为独特的因素GTPase dy-namin在裂变中起着关键作用。为了提供关于网格蛋白在哺乳动物细胞生理中起作用的所有位点以及依赖网格蛋白的囊泡运输途径的新线索，Iversen等人。 （7）设计了一种哺乳动物细胞系，其中网格蛋白的表达可以被诱导性反义RNA抑制。出乎意料的是，这项研究表明网格蛋白重链在调节动力蛋白表达和功能中的作用。

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