...
【24h】

Mind-altering miniature neurotransmitter release?

机译:改变心灵的微型神经递质释放?

获取原文
获取原文并翻译 | 示例
           

摘要

It is well established that calcium is the trigger for fast action potential-evoked synaptic transmission. After elevation of intracellular calcium ([Ca~(2+)]_i) by action potential-mediated opening of voltage-dependent calcium channels (VDCCs), a low resting rate of neurotransmitter release of 0.01―0.03 vesicles per sec is elevated significantly to ≈20 per sec. Transmitter release occurring independently of action potential-mediated changes in [Ca~(2+)]_i is termed "miniature release" and involves the stochastic release of individual vesicles (quanta). The quantal nature of miniature activity has been used to elucidate basic functional parameters of central nervous system (CNS) and neuromuscular synapses.
机译:众所周知,钙是引起快速动作电位诱发的突触传递的触发因素。通过动作电位介导的电压依赖性钙通道(VDCCs)的开放而升高细胞内钙([Ca〜(2 +)] _ i)后,神经递质释放的低静息率0.01-0.03囊泡/秒显着提高至≈20秒独立于[Ca〜(2 +)] _ i的动作电位介导的变化而发生的变送器释放被称为“微型释放”,涉及单个囊泡(量子)的随机释放。微型活动的数量性质已被用来阐明中枢神经系统(CNS)和神经肌肉突触的基本功能参数。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号