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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Evidence for neurogenesis in the adult mammalian substantia nigra
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Evidence for neurogenesis in the adult mammalian substantia nigra

机译：成年哺乳动物黑质中神经发生的证据

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摘要

New neurons are generated from stem cells in a few regions of the adult mammalian brain. Here we provide evidence for the generation of dopaminergic projection neurons of the type that are lost in Parkinson's disease from stem cells in the adult rodent brain and show that the rate of neurogenesis is increased after a lesion. The number of new neurons generated under physiological conditions in substantial nigra pars compacta was found to be several orders of magnitude smaller than in the granular cell layer of the dentate gyrus of the hippocampus. However, if the rate of neuronal turnover is constant, the entire population of dopaminergic neurons in substantia nigra could be replaced during the lifespan of a mouse. These data indicate that neurogenesis in the adult brain is more widespread than previously thought and may have implications for our understanding of the pathogenesis and treatment of neurodegenerative disorders such as Parkinson's disease. [References: 33]
机译：新的神经元是从成年哺乳动物脑部几个区域的干细胞中产生的。在这里，我们提供了成年啮齿动物脑干细胞中在帕金森氏病中丢失的多巴胺能投射神经元类型的证据，并显示了病变后神经发生的速率增加。发现在生理条件下，在紧密黑质致密部中产生的新神经元的数量比海马齿状回的颗粒细胞层小几个数量级。但是，如果神经元更新的速率恒定，则黑质中的多巴胺能神经元的整个种群可以在小鼠的寿命期内被替换。这些数据表明，成年大脑中的神经发生比以前认为的更为广泛，可能对我们对神经退行性疾病（如帕金森氏病）的发病机理和治疗的理解有影响。 [参考：33]

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