...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Transglutaminase 2(-/-) mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells
【24h】

Transglutaminase 2(-/-) mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells

机译：转谷氨酰胺酶2（-/-）小鼠揭示巨噬细胞和凋亡细胞之间的吞噬作用相关串扰

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Tissue transglutaminase (TGase2) is a protein-crosslinking enzyme known to be associated with the in vivo apoptosis program. Here we report that apoptosis could be induced in TGase2(-/-) mice; however, the clearance of apoptotic cells was defective during the involution of thymus elicited by dexamethasone, anti-CD3 antibody, or gamma-irradiation, and in the liver after induced hyperplasia. The lack of TGase2 prevented the production of active transforming growth factor-beta1 in macrophages exposed to apoptotic cells, which is required for the up-regulation of TGase2 in the thymus in vivo, for accelerating deletion of CD4+CD8+ cells and for efficient phagocytosis of apoptotic bodies. The deficiency is associated with the development of splenomegaly, autoantibodies, and immune complex glomerulonephritis in TGase2(-/-) mice. These findings have broad implications not only for diseases linked to inflammation and autoimmunity but also for understanding the interrelationship between the apoptosis and phagocytosis process. [References: 33]
机译：组织转谷氨酰胺酶（TGase2）是一种蛋白质交联酶，已知与体内细胞凋亡程序有关。在这里我们报道，TGase2（-/-）小鼠可以诱导凋亡。然而，在地塞米松，抗CD3抗体或γ射线引起的胸腺退化以及诱导增生后的肝脏中，凋亡细胞的清除是有缺陷的。缺乏TGase2阻止了暴露于凋亡细胞的巨噬细胞中活性转化生长因子β1的产生，这是体内胸腺TGase2上调，加速CD4 + CD8 +细胞缺失和有效吞噬细胞所必需的凋亡小体。该缺陷与TGase2（-/-）小鼠中脾肿大，自身抗体和免疫复合物肾小球肾炎的发展有关。这些发现不仅对与炎症和自身免疫有关的疾病具有广泛的意义，而且对于理解细胞凋亡与吞噬过程之间的相互关系也具有广泛的意义。 [参考：33]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号