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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Regression of established tumors and metastases by potent vascular endothelial growth factor blockade
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Regression of established tumors and metastases by potent vascular endothelial growth factor blockade

机译：通过有效的血管内皮生长因子阻滞消退已建立的肿瘤和转移灶

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Vascular endothelial growth factor (VEGF) is a critical promoter of blood vessel growth during embryonic development and tumorigenesis. To date, studies of VEGF antagonists have primarily focused on halting progression in models of minimal residual cancer. Consistent with this focus, recent clinical trials suggest that blockade of VEGF may impede cancer progression, presumably by preventing neoangiogenesis. However, VEGF is also a key mediator of endothelial-vascular mural cell interactions, a role that may contribute to the integrity of mature vessels in advanced tumors. Here, we report that high-affinity blockade of VEGF, using the recently described VEGF-Trap, abolishes mature, preexisting vasculature in established xenografts. Eradication of vasculature is followed by marked tumor regression, including regression of lung micrometastases. Thus, the contribution of relatively low levels of VEGF to vessel integrity may be critical to maintenance of even very small tumor masses. Potent blockade of VEGF may provide a new therapeutic option for patients with bulky, metastatic cancers. [References: 21]
机译：血管内皮生长因子（VEGF）是胚胎发育和肿瘤发生过程中血管生长的关键启动子。迄今为止，VEGF拮抗剂的研究主要集中于在最小残留癌模型中停止进展。与此焦点一致，最近的临床试验表明，VEGF的阻断可能通过预防新血管生成而阻止了癌症的进展。然而，VEGF还是内皮-血管壁细胞相互作用的关键介体，这一作用可能有助于晚期肿瘤中成熟血管的完整性。在这里，我们报告说，使用最近描述的VEGF-Trap对VEGF进行高亲和力阻断，可以消除已建立的异种移植物中成熟的，预先存在的脉管系统。根除血管后，肿瘤明显消退，包括肺微转移消退。因此，相对低水平的VEGF对血管完整性的贡献对于维持甚至非常小的肿瘤块可能至关重要。强有力的VEGF阻断剂可能为患有大块转移性癌症的患者提供新的治疗选择。 [参考：21]

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