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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Shape bistability of a membrane neck: A toggle switch to control vesicle content release.
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Shape bistability of a membrane neck: A toggle switch to control vesicle content release.

机译：膜颈部的形状双稳性：拨动开关，用于控制囊泡内容物的释放。

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摘要

Shape dynamics and permeability of a membrane neck connecting a vesicle and plasma membrane are considered. The neck is modeled by a lipid membrane tubule extended between two parallel axisymmetric rings. Within a range of lengths, defined by system geometry and mechanical properties of the membrane, the tubule has two stable shapes: catenoidal microtubule and cylindrical nanotubule. The permeabilities of these two shapes, measured as ionic conductivity of the tubule interior, differ by up to four orders of magnitude. Near the critical length the transitions between the shapes occur within less than a millisecond. Theoretical estimates show that the shape switching is controlled by a single parameter, the tubule length. Thus the tubule connection can operate as a conductivity microswitch, toggling the release of vesicle content in such cellular processes as kiss-and-run membrane connections between vesicles and the cell plasma membrane in macrophages is demonstrated.
机译：考虑连接囊泡和质膜的膜颈的形状动力学和渗透性。通过在两个平行的轴对称环之间延伸的脂质膜小管对颈部进行建模。在由膜的系统几何形状和机械性能定义的一定长度范围内，小管具有两种稳定的形状：悬链式微管和圆柱形纳米管。以小管内部的离子电导率衡量的这两种形状的渗透率相差最多四个数量级。在临界长度附近，形状之间的过渡会在不到一毫秒的时间内发生。理论估计表明，形状切换由单个参数（肾小管长度）控制。因此，小管连接可以用作电导率微开关，在诸如巨噬细胞中的囊泡与细胞质膜之间的亲吻和跑动的膜连接这样的细胞过程中切换囊泡内容物的释放。

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